March 2022

Behavioral validation of the University of Michigan REM behavior disorder questionnaire in the synucleinopathies

iRBD /

Many questionnaires have been proposed to collect data related to dream enactment. These are typically validated by reference to objective measurements of polysomnography, which incorporate physiologic recording of muscle activity during sleep. Another approach to such questionnaire validation would be the direct behavioral observations of patients’ sleep. In the course of an ongoing study, we examined […]

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Intertwined Relationship of Mitochondrial Metabolism, Gut
Microbiome and Exercise Potential

Gut Microbiota, Mitochondria /

: The microbiome has emerged as a key player contributing significantly to the humanphysiology over the past decades. The potential microbial niche is largely unexplored in the contextof exercise enhancing capacity and the related mitochondrial functions. Physical exercise can influence the gut microbiota composition and diversity, whereas a sedentary lifestyle in association withdysbiosis can lead

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Microbiome and Exercise Potential Read More »

The gut microbiome and mental health: advances in research and emerging priorities

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

The gut microbiome exerts a considerable influence on human neurophysiology and mental health. Interactions between intestinal microbiology and host regulatory systems have now been implicated both in the development of psychiatric conditions and in the efficacy of many common therapies. With the growing acceptance of the role played by the gut microbiome in mental health

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Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Biomarkers, Constipation, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in

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Associations between Drinking Water Source and Gut Microbiota Composition in the American Gut Project Database

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

The gut microbiome exerts a fundamental role in host physiology. Extrinsic factors such as lifestyle and diet are widely recognized as the main drivers of gut microbiota composition [1, 2]. While drinking water is among the food items consumed in the largest amount, little is known about its potential impact on gut microbiota structures [3-5]. Objective: We explored

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The Antioxidants Glutathione, Ascorbic Acid and Uric Acid Maintain Butyrate Production by Human Gut Clostridia in The Presence of Oxygen In Vitro

Butyrate, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Uncontrolled oxidative stress, reported in Salmonella and HIV infections, colorectal cancer or severe acute malnutrition, has been associated with anaerobic gut microbiome alteration, impaired butyrate production, mucosal immunity dysregulation and disruption of host-bacterial mutualism. However, the role of major antioxidant molecules in the human body, such as glutathione, ascorbic acid and uric acid, has been neglected in

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Oral microbiomes: more and more importance in oral cavity and whole body

Oral Microbiome, Periodontitis /

Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play

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Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota

Butyrate, Oral Microbiome, Periodontitis /

Postmenopausal osteoporosis (PMO) is a risk factor for periodontitis, and current therapeutics against PMO prevent the aggravated alveolar bone loss of periodontitis in estrogen-deficient women. Gut microbiota is recognized as a promising therapeutic target for PMO. Berberine extracted from Chinese medicinal plants has shown its effectiveness in the treatment of metabolic diseases such as obesity

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Oral microbiota in human systematic diseases

Oral Microbiome, Periodontitis /

Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the

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Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease—Is There Cause for Consideration?

Butyrate, Metabolites, Oral Microbiome, Periodontitis, Short Chain Fatty Acids /

Cardiovascular diseases, chronic obstructive pulmonary diseases, diabetes, rheumatoid arthritis, and cancer are the most common noncommunicable diseases (NCDs). These NCDs share risk factors with periodontal disease (PD), a preventable risk factor linked to lifestyle. The discussion regarding the association between these chronic diseases is more complex. There is still a significant knowledge gap particularly of

Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease—Is There Cause for Consideration? Read More »