The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neu-roprotective effects, particularly in the Lachnospiraceae family and key members,such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, andBlautia. The direct evalua-tion of fecal metabolites revealed changes in several classes of metabolites. Changeswere seen in lipids (linoleic acid, oleic acid, succinic acid, and sebacic acid), vitamins (pantothenic acid and nicotinic acid), amino acids (isoleucine, leucine, phenylalanine,glutamic acid, and pyroglutamic acid) and other organic compounds (cadaverine,ethanolamine, and hydroxy propionic acid). Most modified metabolites strongly cor-related with the abundance of members belonging to the Lachnospiraceae family,suggesting that these gut bacteria correlate with altered metabolism rates in Parkin-son’s disease
(4) (PDF) Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease Downloaded from. Available from: https://www.researchgate.net/publication/344283343_Gut_Microbiota_and_Metabolome_Alterations_Associated_with_Parkinson’s_Disease_Downloaded_from [accessed Jan 31 2021].