Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk of AD, PD and ALS, and
we revealed several causal relationships. These findings may provide new targets for treatment of these neurodegenerative diseases, and may offer valuable
insights for further researches on the underlying mechanisms.
In summary, gut microbiota plays a crucial role in normal development and maintenance of brain function. Our study first applied a MR study to reveal causal
relationships between some specific gut microbiota, metabolites and risks of AD, PD or ALS. However, extensive additional works are still required to
characterize the effects of the microbiota-gut-brain axis on neurodegenerative diseases, and to find potential treatments by altering gut microbiota
compositions. CLICK TO REVIEW