The presented data of preclinical studies showed that harmine hydrochloride has antidepressant,
antihypoxic, and antiparkinsonian effects, eliminates catalepsy caused by haloperidol in rats, and reduces
oligokinesia and rigidity in the parkinsonian syndrome test. In terms of antiparkinsonian effect, harmine hydrochloride
is not inferior to amitriptyline. The study of the relative bioavailability of harmine hydrochloride in experimental
animals showed that harmine hydrochloride is absorbed much faster when administered orally, quickly reaching the
highest concentration in blood plasma. Based on the results of molecular docking, the presence of strong bonds in
harmine hydrochloride with monoamine oxidases A and B was revealed, which indicates the implementation of the
mechanism of the antidepressant action of the alkaloid at the level of synoptic neurotransmission. CLICK TO REVIEW