We have briefly expressed three components that are significant in promoting the complex involvement of the gut within PD. Thorough research has looked into the physiology and symptoms of PD, with further exploration into the gut microbiota a crucial step in truly understanding the disease process. Adopting strategies to ensure stable, healthy microbial consumption along with lifestyle modification may be the next step in targeting the disease process and the health-economic burden. We welcome further research into this field as only time will tell whether treating the second brain is a fact or fantasy. CLICK TO REVIEW