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Role of the Gut Microbiome and Its Modulation in Neurodegenerative Diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Neurodegenerative disorders are progressive conditions of the central nervous system (CNS), resulting in increased morbidity and mortality. The gut microbiome is a microecosystem that consists of billions of bacteria and fungi, most of which are of good benefit to the human body’s internal milieu via regulating the immune system and controlling the neuronal signals intertwining […]

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Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD

Ayahuasca, Parkinson's Disease /

Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitivedysfunctions. Pharmacological interventions to slow the progression of AD are intensively studied. Apotential direction targets neuronal sigma-1 receptors (S1Rs). S1R ligands are recognized as promisingtherapeutic agents that may alleviate symptom severity of AD, possibly via preventing amyloid-β-(Aβ-) induced neurotoxicity on the endoplasmic reticulum

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD Read More »

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Fasting /

Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function Read More »

Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study

iRBD, Parkinson's Disease /

Our study showed the intriguing possibility that the disease course of iRBD patients differed according to the degree of polygenic burden of PD risk SNPs, although future validation is warranted. CLICK TO REVIEW

Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study Read More »

Western and ketogenic diets in neurological disorders: can you
tell the difference?

Diet and Exercise, Parkinson's Disease /

The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption of the high-fat, high-carbohydrate Western diet, which predisposes to the development of the metabolicsyndrome and correlates with decreased cognitive

Western and ketogenic diets in neurological disorders: can you
tell the difference? Read More »

Effects of an low carbohydrate/healthy
fat/ketogenic diet on biomarkers of health
and symptoms, anxiety and depression in
Parkinson’s disease: a pilot study

Diet and Exercise, Lectins /

To evaluate a low carbohydrate/healthy fat/ketogenic diet (LCHF/KD) on symptoms, depression,anxiety and biomarkers in adults with Parkinson’s disease (PD). Patients & methods: 16 adults ages 36–80with PD participated in the intervention for 12 weeks. The study provided pre-post-study comparisonsof biomarkers, weight, waist measurement, united Parkinson’s Disease Rating Scale (UPDRS), Parkinson’sAnxiety Scale (PAS) and Center for

Effects of an low carbohydrate/healthy
fat/ketogenic diet on biomarkers of health
and symptoms, anxiety and depression in
Parkinson’s disease: a pilot study Read More »

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

Diet and Exercise, Gut Microbiota /

Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota Read More »

Gastrointestinal Microbiome and Neurologic Injury

Butyrate, Constipation, ENS, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

: Communication between the enteric nervous system (ENS) of the gastrointestinal (GI)tract and the central nervous system (CNS) is vital for maintaining systemic homeostasis. Intrinsicand extrinsic neurological inputs of the gut regulate blood flow, peristalsis, hormone release, andimmunological function. The health of the gut microbiome plays a vital role in regulating the overallfunction and well-being

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A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Butyrate, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated with both the potential functionality of the gut microbiota and the biological mechanisms thought to be underpinning mental disorders. In this

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia Read More »

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »