Gut microbiota alterations in Parkinson’s disease (PD) have been found in several studies and are suggested to contribute to the pathogenesis of PD. However, previous results could not be adequately adjusted for a potential confounding effect of PD medication and disease duration, as almost all PD participants were already using dopaminergic medication and were included […]
The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modification trials in PD has been attributed to a variety of factors related not only to choosing wrong interventions, but also to using inadequate
Prodromal Parkinson’s disease: hype or hope for disease-modification trials? Read More »
The functions of the complement system to both innate and adaptive immunity throughopsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond immunity, is only beginning to berecognized as important to neurodevelopment and neurodegeneration. In addition to protecting thebrain against invasive
We found increasing gut-dysbiosis with worsening symptoms in sALS patients and increasing oral-dysbiosis with worsening symptoms in bALS patients. Our findings support distinct microbial mechanisms underlying two ALS subtypes, which have been previously grouped together as a single disease. Our study suggests correcting gut-dysbiosis as a therapeutic strategy for sALS patients and correcting oral-dysbiosis as
The mammalian circadian system is a hierarchically organized system, which controls a24-h periodicity in a wide variety of body and brain functions and physiological processes. Thereis increasing evidence that the circadian system modulates the complex multistep process of adultneurogenesis, which is crucial for brain plasticity. This modulatory effect may be exercised viarhythmic systemic factors including
Adult Neurogenesis under Control of the Circadian System Read More »
Neurodegenerative diseases are hitherto classified based on their core clinical features, the anatomical distribution of neurodegeneration, and the cell populations mainly affected. On the other hand, the wealth of neuropathological, genetic, molecular and biochemical studies have identified the existence of distinct insoluble protein aggregates in the affected brain regions. These findings have spread the use of a
Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological evidence is limited. This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream-enacting behaviors. CLICK
High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers Read More »
Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression. From our translational study, which included 3 animal models
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally invital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protectionagainst the development of neurological diseases. Emerging evidence shows that gut microbiotahave significant roles in maintaining adequate concentrations of
Role of Microbiota-Gut-Brain Axis in Regulating
Dopaminergic Signaling Read More »
Regular treadmill exercise is more efficient than voluntary in neuroprotection by changing brain metabolism, at the moment, regulartreadmill exercise has been observed to improve many physiological impacts in humans and animals. The present study sought to verifythe effect of regular treadmill exercise on brain-derived neurotrophic factor (BDNF) and irisin in healthy adult’s men in Basra