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Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases?

endondonics, Endotoxin, Periodontitis /

Apical periodontitis (AP) or periapical lesion (PL) is an inflammatory disease that causes pain, loss of bone and destruction of other tissues of teeth support. This condition could be caused by caries, dental trauma and/or periapical microleakage wich is regulated by the immune system or inflammatory response. Several analyses have shown that endodontic infection can […]

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Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each

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Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The role of gut bacteria in neurodegenerative disease has long been speculated; however, the extent of influence and the exact composition of microflora that mechanistically alter outcomes are less understood. While aging was thought to be a major contributor to neurodegenerative disease, the role of the immune system started to become more appreciated bringing the

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Impaired Ocular Tracking and Cortical Atrophy in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

iRBD, Optial, Pre-PD /

We found ocular-tracking abnormalities in patients with iRBD even early in their disease progression that have not been reported before. These abnormalities are coupled with atrophy of brain areas involved in the perception of object motion and might indicate phenoconversion to synucleinopathies in iRBD. © 2022 International Parkinson and Movement Disorder Society. CLICK TO REVIEW

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The Mediterranean Diet as a Source of Bioactive Molecules with
Cannabinomimetic Activity in Prevention and Therapy Strategy

Herbs & Spices, Vitamins / Supplements / Nutraceuticals /

The endocannabinoid system is a complex lipid signaling network that has evolved tobe a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerousprocesses has rendered it a very suitable target for pharmacological studies regarding metabolicsyndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have beenfound in a large variety of foods, most of

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Cannabinomimetic Activity in Prevention and Therapy Strategy Read More »

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Background Parkinson’s disease (PD) is a prevalent and debilitating condition. Conventional medications cannot control all symptoms and may inflict adverse effects. A survey reported that Chinese herbal medicine (CHM) is frequently sought. Existing CHM trials were contradictory and often of poor quality due to lack of methodological rigor. A national clinical guideline was drafted in

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A CLOSER LOOK AT THE MYCOBIOME IN ALZHEIMER’S DISEASE: FUNGAL SPECIES, PATHOGENESIS AND TRANSMISSION

Uncategorized /

Candida spp., Malassezia spp., Cladosporium spp. and Alternaria spp are among the most common fungi detected in the brain of patients with Alzheimer’s disease (AD). These fungi are opportunistic organisms, where they often cause infection among immunocompromised patients. Coincidentally, these fungi can reach the brain and cause fungal meningitis. In general, they enter the brain via systemic infection due to disrupted epithelial

A CLOSER LOOK AT THE MYCOBIOME IN ALZHEIMER’S DISEASE: FUNGAL SPECIES, PATHOGENESIS AND TRANSMISSION Read More »

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease

Anti-oxidants, Autophagy, Diet and Exercise, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung

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Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Vagal Nerve /

There has been exponential growth in the awareness and understanding of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) over the past 3 decades. The clinical features of GI dysfunction in PD have been clearly identified and innovative research has demonstrated the presence of pathology within the enteric nervous system (ENS) in individuals with PD, leading

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Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study

iRBD, Pre-PD /

Background:Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective:To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods:Patients with iRBD were

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