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How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson’s disease

A-Synuclein, Mitochondria, Viral / Bacterial Infections /

The cause of most Parkinson’s disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction […]

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Be well: A potential role for vitamin B in COVID-19

Virus, Vitamins / Supplements / Nutraceuticals /

There is a need to highlight the importance of vitamin B because it plays a pivotal role in cell functioning, energy metabolism, and proper immune function. Vitamin B assists in proper activation of both the innate and adaptive immune responses, reduces pro-inflammatory cytokine levels, improves respiratory function, maintains endothelial integrity, prevents hypercoagulability and can reduce

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Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease

Biomarkers, Pre-PD, Symptoms / Diagnosis /

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health

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Acupoint Massage Therapy Alters the Composition of Gut Microbiome in Functional Constipation Patients

Biomarkers, Gut Dysbiosis, Gut Microbiota, Symptoms / Diagnosis /

The 16S KEGG function prediction suggested that Parkinson disease, retinol metabolism, and arachidonic acid metabolism could explain the biological function of different gut microbiome. Furthermore, cytokines in the serum showed a correlation with the abundance of Pseudobutyrivibrio in CFC. Conclusion. AMT could change the composition of gut microbiome which is associated with cytokines in CFC patients. CLICK TO

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Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health

Butyrate, Diet and Exercise, Gut Microbiota /

Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression. In this review, we discuss each of these concepts to understand how what we eat

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Physical activity as a mediator of anxiety and cognitive functioning in Parkinson’s disease

Diet and Exercise /

Analyses revealed a significant direct effect of anxiety predicting cognitive functioning. Additionally, there was a significant indirect within-person effect; meaning that individuals who became more anxious over time, they also reported becoming less physically active, which was subsequently associated with longitudinal declines in cognitive functioning. CLICK TO REVIEW

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Olfactory impairment as an early marker of Parkinson’s disease in REM sleep behavior disorder: a systematic review and meta-analysis

Biomarkers, iRBD, Olfactory /

We identified similar olfactory impairments in patients with RBD and patients with PD (either with or without underlying RBD). These findings suggest that olfactory impairment may be a sensitive and stable diagnostic biomarker of RBD and appears to be useful for identifying patients with idiopathic RBD at high risk for early conversion to PD. CLICK

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Probiotics : A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut–Brain Interaction

Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Abstract: Various benefits of probiotics to the host have been shown in numerous human clinical trials. These organisms have been proposed to act by improving the balance of the gut microbiota and enhancing the production of short-chain fatty acids, as well as by interacting with host cells in the gastrointestinal tract, including immune cells, nerve

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