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The potential of human milk oligosaccharides to impact the microbiota-gutbrain axis through modulation of the gut microbiota

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

ABSTRACT: Human milk oligosaccharides (HMOs) are the first prebiotics humans meet in life. HMOs provide many benefits to infants including impact on gut bacteria, promotion of postnatal brain development, and modulation of the immune system. A complex bidirectional communication pathway called the microbiota-gut-brain axis links gut homeostasis and microbial composition with the central nervous system […]

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Probiotic Bacillus subtilis Protects against a-Synuclein Aggregation in C. elegans

A-Synuclein, Probiotics, Prebiotics and Symbiotics /

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits a synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. CLICK TO REVIEW

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Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . .

A-Synuclein, Gut-Brain axis, Mitochondria /

ABSTRACT: Here, we give an overview of the progress that has been made over the past four decades in our understanding of this disorder. We review the role of mitochondria, environmental toxicants, alpha-synuclein and neuroinflammation in the development of PD. We also discuss more recent data from genetics, which strongly support the endosomal-lysosomal pathways and

Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . . Read More »

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

iRBD /

During rapid eye movement (REM) sleep, anti-gravity muscle tone and bodily movements are mostly absent, because somatic motoneurons are inhibited by descending inhibitory pathways. Recent studies showed that glycine/GABA neurons in the ventromedial medulla (VMM) (GlyVMM neurons) play an important role in generating muscle atonia during REM sleep (REM-atonia). CLICK TO REVIEW

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice Read More »

Gut microbiota: a potential therapeutic target for Parkinson’s disease

Gut Dysbiosis, Gut Microbiota /

If therapeutic manipulation of gut microbiota proves effective to treat some pathogenic aspects of PD, an important inquiry would be at which point of the disease evolution these therapies should be implemented. It is accepted that microbiota conformation is shaped early in life with relative minor changes later on. However, patients with rapid eye movement-sleep

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Increasing Comparability and Utility of Gut Microbiome Studies in Parkinson’s Disease: A Systemic Review

Gut Microbiota /

To move from the current heterogeneous dataset towards clinically relevant biomarkers and the identification of putative therapeutic targets, recommendations are derived from the limitations of the available studies to increase the future comparability of microbiome studies in PD. In addition, integration of currently available data on the gut microbiome in PD is proposed to identify

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Effects of dietary restriction on neuroinflammation in neurodegenerative diseases

Diet and Exercise, Gut Microbiota /

Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative

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Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics

Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Pre-clinical and human clinical trial data reveal exciting potential for novel treatment targets and therapeutic modulation with prebiotics, medicinal herbs, probiotics, and synbiotics in health, aging, and neurodegeneration and are reviewed here. While greater insights and characterization of the microbiota-gut-brain axis have been revealed over the past decade, salient questions related to the pathology, pathogenesis

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics Read More »

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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