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Fecal transplants as a microbiome-based therapeutic

Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance patients’ microbiomes. Recent evidence has demonstrated that bacterial and viral richness, short

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COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D

We previously reported a north–south gradient in global COVID-19 mortality but were conscious that lack of ultraviolet exposure and consequent vitamin D insufficiency was not the only possible explanation. We have now investigated the relationships between latitude, age of population, population density and pollution with COVID-19 mortality   CLICK TO REVIEW

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SARS-CoV-2 positivity rates associated with
circulating 25-hydroxyvitamin D levels

Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity

SARS-CoV-2 positivity rates associated with
circulating 25-hydroxyvitamin D levels
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A rapid a-synuclein seed assay of Parkinson’s disease CSFpanel shows high diagnostic accuracy

Assays that specifically measure a-synuclein seeding activity inbiological fluids could revolutionize the diagnosis of Parkinson’s disease. Recentimprovements in a-synuclein real-time quaking-induced conversion assays ofcerebrospinal fluid have dramatically reduced reaction times from 5-13 daysdown to 1-2 days.    Click here for report

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A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy

Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson’s disease while maintaining the high-performance standards associated with previous α-synuclein seed assays, supporting the clinical utility of this assay for Parkinson’s disease diagnosis.  https://doi.org/10.1002/acn3.51280

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How Your Gut Health Impacts Your Disease Risk

More attention than ever is being put on your gut health, and understandably so, considering a significant proportion of your immune system resides in your gastrointestinal tract.1 As such, optimizing your gut microbiome is a worthwhile pursuit that will have far-reaching effects on your physical health and emotional well-being. Mounting scientific evidence also continues to suggest

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Managing the Microbiome – How the Gut Influences Development and Disease

The microbiome lies at the forefront of scientific research, as researchers work to uncover its mysterious influence on human development and disease.  Though the clinical applications of microbiome manipulation are currentlylimited, the significance of dysbiosis in the etiology of a wide array of diseases indicates the significance of this research and highlights the need for

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