In response to behaviorally salient stimuli, dopamine (DA) neuronsfire in bursts. These data show that the LDTg is critical to normal DA function,and thus, pathology within this region may lead to aberrant DAsignaling. http://www.pnas.orgcgidoi10.1073pnas.0510715103
Neurodegenerative diseases, Parkinson disease among them, set challenges to modern societies both in terms of premature deaths and resources spent on treatment of the diseases. At that, preventive care and early diagnostics in particular are potential directions towards higher economic efficiency of healthcare interventions in this area. https://doi.org/10.3897/popecon.4.e59949
A large and convincing body of evidence demonstrated that aging is characterized by a progressive decline in the efficiency of physiological functions due to the consequence of free radical-induced damage to cellular macromolecules. https://doi.org/10.1155/2018/3416028
The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression. These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression. https://doi.org/10.1155/2017/6405278
Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression Read More »
Sleep Disorders (SDs) precede motor symptoms of Parkinson’s disease (PD), suggesting an early effect of disease processes on sleep control neurons. These nucleus-specific differential effects suggest previously unappreciated, mechanistic underpinnings of SDs’ prodromal PD appearance in PD, and wehypothesize that in the prodromal phase of PD, the early form of α-synuclein compromises sleep-control neurons. https://doi.org/10.21203/rs.3.rs-134060/v1
Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially vulnerable. Here, we bring together evidence that the development and presence of PD depends on specific sets of interlinking factors
Most middle-aged and older adult patients with isolated (idiopathic) REM sleep behavior disorder (RBD) eventually develop parkinsonism, dementia with Lewy bodies, or multiple system atrophy. https://doi.org/10.1016/j.sleep.2020.12.014
Specialist Approaches to Prognostic Counseling in Isolated REM Sleep Behavior Disorder Read More »