Have We Discovered the Cause of Alzheimer’s, Parkinson’s, and ALS?
Have We Discovered the Cause of Alzheimer’s, Parkinson’s, and ALS? Read More »
Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion
Background Hypomethylation of intron 1 of the α‐synuclein (SNCA) gene has been extensively reported in the blood of patients with α‐synucleinopathies. Idiopathic rapid eye movement sleep behavior disorder represents a prodromal stage of α‐synucleinopathies. Methylation of α‐synuclein intron 1 in idiopathic rapid eye movement sleep behavior disorder patients is largely unexplored. The objective of the
Physiological and pathological changes in the enteric nervous system of rotenone-exposed mice as early biomarkers for Parkinson´s disease
Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients like constipation, that can precede the appearance of motor symptoms by years. We have shown that environmental toxins can trigger the disease by acting on the ENS and
Copper oxide nanoparticles promote α-synuclein oligomerization and underlying neurotoxicity as a model of Parkinson’s disease
Parkinson’s disease is associated with the formation of protein aggregates called amyloid fibrils. α-synuclein amyloid accumulation is known to be a key factor in the development of neuronal degenerative diseases in the brain, and exploring some toxic compounds with biomedical application like copper oxide (CuO) nanoparticles that can promote protein aggregation and underlying cytotoxicity are
Gut-Brain Axis in Parkinson’s disease Etiology: The Role of Lipopolysaccharide
Recent studies highlight the initiation of Parkinson’s disease (PD) in the gastrointestinal tract, decades before the manifestations in the central nervous system (CNS). This gut-brain axis of neurodegenerative diseases defines the critical role played by the unique microbial composition of the “second brain” formed by the enteric nervous system (ENS) https://doi.org/10.1016/j.chemphyslip.2020.105029
Gut-Brain Axis in Parkinson’s disease Etiology: The Role of Lipopolysaccharide Read More »
Effects of ketogenic diet containing medium-chain fatty acids on serum inflammatory factor and mTOR signaling pathway in rats
The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. https://doi.org/10.1186/s40538-020-00194-4
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson’s disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an initiator, propagator, or bystander remains undetermined. The discovery of the role of the PD familial genes PTEN-induced putative kinase 1 ( PINK1) and parkin ( PRKN) in mediating mitochondrial degradation (mitophagy) reaffirmed the
An evaluation of the feasibility of utilizing Virtual Reality as a tool to assess cognitive function
Virtual reality (VR) is currently being studied to determine its’ possible uses within healthcare, for example to assess cognitive impairment. This project investigates the feasibility of utilizing VR to assess cognitive function in a clinical setting. The report begins with a literature study investigating various aspects of VR and cognitive impairment, with a certain focus