Parkinson’s Disease

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality […]

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

According to psychobiotic research expansion, the gut microbiome—a colony of more than 1000 species—is connected to brainhealth and state of mind. Historically, even though a variety of body parts and systems were linked to the nervous system in thenineteenth century, researchers began began researching the gut, especially the stomach, calling it ‘the great abdominal brain’,

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders Read More »

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

THE MICROBIOTA-GUT-BRAIN AXIS

A-Synuclein, Butyrate, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However,the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms withinand on our bodies) as one of the key regulators of gut-brain function and has led to the appreciationof the importance of a distinct microbiota-gut-brain axis.This axis

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Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

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Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management

Biomarkers, Constipation, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease /

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson’s disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation

Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management Read More »

Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study

Diet and Exercise, Parkinson's Disease, Pre-PD /

The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson’s disease (pPD) probability and incidence among community-dwelling older individuals without clinical features of parkinsonism at baseline. More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older

Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study Read More »

Dual role of the nasal microbiota in neurological diseases—An unignorable risk factor or a potential therapy carrier

Gut Dysbiosis, Mitochondria, Olfactory, Parkinson's Disease /

Recently, comparative studies have rapidly increased with the closer correlation between microbiota and neurological diseases. However, most insights about the association between microbiota and neurological diseases still focus on the gut-brain axis and ignore that nasal microbiota could form a complex and essential link with the nervous system via the nose-to-brain pathway, suggesting the role

Dual role of the nasal microbiota in neurological diseases—An unignorable risk factor or a potential therapy carrier Read More »

Effects of Cannabidiol on Parkinson’s Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis

CBD, Parkinson's Disease /

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical PD motor symptoms. The therapeutic effect of cannabidiol (CBD) on PD has been a research frontier in recent years. However, the pathogenesis of PD and the therapeutic mechanism of cannabinoid remain unclear. To further

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Alpha-Synuclein-Specific Naturally Occurring Antibodies
Inhibit Aggregation In Vitro and In Vivo

A-Synuclein, Parkinson's Disease /

Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of theinnate immune system, produced without prior contact to their specific antigen, and polyreactive.The abundance of nAbs against αSyn is altered in patients with PD. In this work, we biophysicallycharacterized nAbs against

Alpha-Synuclein-Specific Naturally Occurring Antibodies
Inhibit Aggregation In Vitro and In Vivo Read More »