Parkinson’s Disease

Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Biomarkers, Constipation, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in […]

Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS Read More »

Effects of Intermittent Fasting On Cognition and
Neurodegeneration

Fasting, Parkinson's Disease /

Intermittent fasting (IF) can facilitate neurodegenerative, neuroadaptive and neuroprotective processes leading toprofound effects on cognition and dementias. The impact that IF has on the central nervous system is still not fullyknown. Several factors come into likely effect including changes in energy metabolism, oxidative damage, insulinsensitivity, inflammation, and functional changes related to various neurotransmitters and hormones.

Effects of Intermittent Fasting On Cognition and
Neurodegeneration Read More »

Role of the Gut Microbiome and Its Modulation in Neurodegenerative Diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Neurodegenerative disorders are progressive conditions of the central nervous system (CNS), resulting in increased morbidity and mortality. The gut microbiome is a microecosystem that consists of billions of bacteria and fungi, most of which are of good benefit to the human body’s internal milieu via regulating the immune system and controlling the neuronal signals intertwining

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Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD

Ayahuasca, Parkinson's Disease /

Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitivedysfunctions. Pharmacological interventions to slow the progression of AD are intensively studied. Apotential direction targets neuronal sigma-1 receptors (S1Rs). S1R ligands are recognized as promisingtherapeutic agents that may alleviate symptom severity of AD, possibly via preventing amyloid-β-(Aβ-) induced neurotoxicity on the endoplasmic reticulum

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084
and DMT, on Neurogenesis and Neuroinflammation in an
Aβ1-42-Injected, Wild-Type Mouse Model of AD Read More »

Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study

iRBD, Parkinson's Disease /

Our study showed the intriguing possibility that the disease course of iRBD patients differed according to the degree of polygenic burden of PD risk SNPs, although future validation is warranted. CLICK TO REVIEW

Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study Read More »

Western and ketogenic diets in neurological disorders: can you
tell the difference?

Diet and Exercise, Parkinson's Disease /

The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption of the high-fat, high-carbohydrate Western diet, which predisposes to the development of the metabolicsyndrome and correlates with decreased cognitive

Western and ketogenic diets in neurological disorders: can you
tell the difference? Read More »

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »

Gut microbiome alterations in fecal samples of treatment-naïve de novo Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Gut microbiota alterations in Parkinson’s disease (PD) have been found in several studies and are suggested to contribute to the pathogenesis of PD. However, previous results could not be adequately adjusted for a potential confounding effect of PD medication and disease duration, as almost all PD participants were already using dopaminergic medication and were included

Gut microbiome alterations in fecal samples of treatment-naïve de novo Parkinson’s disease patients Read More »

Prodromal Parkinson’s disease: hype or hope for disease-modification trials?

Biomarkers, Parkinson's Disease, Pre-PD /

The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modification trials in PD has been attributed to a variety of factors related not only to choosing wrong interventions, but also to using inadequate

Prodromal Parkinson’s disease: hype or hope for disease-modification trials? Read More »

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers

iRBD, Parkinson's Disease, Pesticides, Pre-PD /

Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological evidence is limited. This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream-enacting behaviors. CLICK

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers Read More »