Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression. From our translational study, which included 3 animal models […]
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally invital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protectionagainst the development of neurological diseases. Emerging evidence shows that gut microbiotahave significant roles in maintaining adequate concentrations of
Role of Microbiota-Gut-Brain Axis in Regulating
Dopaminergic Signaling Read More »
The use of psychedelics as medicines and for overall better brain health is potentially one of the mosttransformative developments given their immediate and long-lasting therapeutic effects across a plethoraof neuropsychiatric disorders and, more recently, some neurodegenerative diseases. The US psychedelicdrugs market is forecasted to grow by 16.3% by 2027 due to the increasing prevalence of
The promise of psychedelic research Read More »
Parkinson’s disease (PD) is a threatening neurodegenerative disorder that seriously affects patients’ life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (α-Syn) to PD. α-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic
α-Synuclein in Parkinson’s disease and advances in detection Read More »
Parkinson’s disease (PD) is a progressive neurodegenerative disease, causing loss of motor and nonmotor function. Diagnosis is based on clinical symptoms that do not develop until late in the disease progression, at which point the majority of the patients’ dopaminergic neurons are already destroyed. While many PD cases are idiopathic, hereditable genetic risks have been
Plasma Metabolite Signature Classifies Male LRRK2 Parkinson’s Disease Patients Read More »
Parkinson’s disease (PD) is one of the first diseases where digital biomarkers demonstrated excellent performance in differentiating disease from healthy individuals. However, no study has systematically compared and leveraged multiple types of digital biomarkers to predict PD. Particularly, machine learning works on the fine-motor skills of PD are limited. Here, we developed deep learning methods
Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can
Parkinson’s disease: Are gut microbes involved? Read More »
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms’ including compromised intestinal barrier function often accompanies altered gut microbiota composition and motor deficits in PD. Therefore, in this study, we set to investigate the role of gut microbiota and epithelial barrier dysfunction on motor symptom
Evidence has demonstrated that endurance training (ET) reduces the motor signs of Parkinson’s disease (PD). However, there has not been a comprehensive meta-analysis of studies to date. ET is effective in decreasing UPDRS-III scores. Questions remain about the dose–response relationship between ET and reduction in motor signs. CLICK TO REVIEW
Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent