Parkinson’s Disease

Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each […]

Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity Read More »

Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The role of gut bacteria in neurodegenerative disease has long been speculated; however, the extent of influence and the exact composition of microflora that mechanistically alter outcomes are less understood. While aging was thought to be a major contributor to neurodegenerative disease, the role of the immune system started to become more appreciated bringing the

Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease Read More »

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Background Parkinson’s disease (PD) is a prevalent and debilitating condition. Conventional medications cannot control all symptoms and may inflict adverse effects. A survey reported that Chinese herbal medicine (CHM) is frequently sought. Existing CHM trials were contradictory and often of poor quality due to lack of methodological rigor. A national clinical guideline was drafted in

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial Read More »

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease

Anti-oxidants, Autophagy, Diet and Exercise, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease Read More »

Gut Microbiota and Short Chain Fatty Acids: Implications in
Glucose Homeostasis

Biomarkers, Butyrate, Gut Microbiota, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

: Gut microbiota encompasses a wide variety of commensal microorganisms consisting oftrillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host,and related metabolites have profound effects on human health. In this respect, gut microbiota playsa pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolitesinclude the short

Gut Microbiota and Short Chain Fatty Acids: Implications in
Glucose Homeostasis Read More »

Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied

Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease Read More »

Classifying Idiopathic Rapid Eye Movement Sleep Behavior Disorder, Controls, and Mild Parkinson’s Disease Using Gait Parameters

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

Gait parameters and a pretrained statistical model can robustly distinguish participants with iRBD from HCs and patients with PD. This could be used to screen subjects with future synucleinopathies in the general population and to identify a conversion threshold to PD. CLICK TO REVIEW

Classifying Idiopathic Rapid Eye Movement Sleep Behavior Disorder, Controls, and Mild Parkinson’s Disease Using Gait Parameters Read More »

Is Fasting Good For Your Brain? The Effects of Fasting on the Brain

Autophagy, Fasting, Parkinson's Disease, Pre-PD /

Fasting promotes autophagy, a vital recycling process, and stimulates the growth factor BDNF. Autophagy is impaired in neurodegenerative conditions such as Alzheimer’s and Parkinson’s. BDNF is crucial for brain health, and low levels are associated with depression. Hence, fasting improves brain health by multiple mechanisms. While fasting has been performed in one form or another

Is Fasting Good For Your Brain? The Effects of Fasting on the Brain Read More »

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease Read More »

Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson’s disease patients

Butyrate, Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Serum SCFAs are altered in PD patients, and the decrease of serum propionic acid level is correlated with motor symptoms, cognitive ability and non-depressed state. Thus, the gut microbial-derived SCFAs potentially affect Parkinson’s symptoms through the blood circulation. Propionic acid supplementation might ameliorate motor and non-motor symptoms of PD patients, although clinical trials are needed

Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson’s disease patients Read More »