Our results suggest that vagotomy has protective effects on
nigrostriatal dopaminergic degeneration and disease progression in
subsequent Parkinson’s disease, but may be unfavorable for cognitive
performance. The neuroprotective effect of vagotomy could be largely
mediated by blocking the spread of α-synuclein from the gut to the brain,
and the modulation of inflammatory response might also contribute to
some extent. CLICK TO REVIEW
Key words: dopaminergic neuron; gastrectomy; neuroprotection;
vagotomy; parkinson’s disease