More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older adult population. Further studies are needed to confirm these findings.
The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may
Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases Read More »
There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection
The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson’s disease (pPD) probability and incidence among community-dwelling older individuals without clinical features of parkinsonism at baseline. More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older
Misfolded protein formation and aggregation are the central hallmarks for various neurodegenerative disorders. When it comes to Parkinson’s disease (PD), alpha-synuclein (α-syn) is the culprit protein. The presence of α-syn protein in lewy bodies and lewy neurites confirmed its presence in the occurrence of PD. The protein is natively present in the soluble monomeric forms,
The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,
Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered. CLICK TO REVIEW
Roles of oral microbiota and oral-gut microbial transmission in hypertension Read More »
: Kefir beverage is a probiotic food associated with health benefits, containing probioticmicroorganisms and biomolecules produced during fermentation. The microbial compositionof these beverages varies among countries, geographical regions, and the substrates, therefore,the characterization of kefir beverages is of great relevance in understanding their potential healthpromoting and biotechnological applications. Therefore, this study presents the metagenomic andfunctional
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical PD motor symptoms. The therapeutic effect of cannabidiol (CBD) on PD has been a research frontier in recent years. However, the pathogenesis of PD and the therapeutic mechanism of cannabinoid remain unclear. To further
Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinalmicrobiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linkedto inflammation. Here, we aim to define the impact of specific foods on bacterial species commonlydepleted in patients with IBD to better inform dietary treatment. We performed a single-arm, prepost