Our findings support a mediating role of the gut microbiome in the beneficial effects of the Green-MED diet enriched with Mankai and green tea on cardiometabolic risk factors. CLICK TO REVIEW
The increased worldwide prevalence of pre-diabetes and diabetes, especially type 2 diabetes, requiring different strategies for their prevention and management. A new focus is the reversal of diabetes dysbiosis, a disruption of gut microbiota homeostasis, which is closely related to elevated blood glucose levels and altered metabolic parameters. In this sense, a balanced diet plays a key role, and,
Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes Read More »
The gut microbiome exerts a fundamental role in host physiology. Extrinsic factors such as lifestyle and diet are widely recognized as the main drivers of gut microbiota composition [1, 2]. While drinking water is among the food items consumed in the largest amount, little is known about its potential impact on gut microbiota structures [3-5]. Objective: We explored
Uncontrolled oxidative stress, reported in Salmonella and HIV infections, colorectal cancer or severe acute malnutrition, has been associated with anaerobic gut microbiome alteration, impaired butyrate production, mucosal immunity dysregulation and disruption of host-bacterial mutualism. However, the role of major antioxidant molecules in the human body, such as glutathione, ascorbic acid and uric acid, has been neglected in
Postmenopausal osteoporosis (PMO) is a risk factor for periodontitis, and current therapeutics against PMO prevent the aggravated alveolar bone loss of periodontitis in estrogen-deficient women. Gut microbiota is recognized as a promising therapeutic target for PMO. Berberine extracted from Chinese medicinal plants has shown its effectiveness in the treatment of metabolic diseases such as obesity
Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota Read More »
Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitivedysfunctions. Pharmacological interventions to slow the progression of AD are intensively studied. Apotential direction targets neuronal sigma-1 receptors (S1Rs). S1R ligands are recognized as promisingtherapeutic agents that may alleviate symptom severity of AD, possibly via preventing amyloid-β-(Aβ-) induced neurotoxicity on the endoplasmic reticulum
Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as
Our study showed the intriguing possibility that the disease course of iRBD patients differed according to the degree of polygenic burden of PD risk SNPs, although future validation is warranted. CLICK TO REVIEW
To evaluate a low carbohydrate/healthy fat/ketogenic diet (LCHF/KD) on symptoms, depression,anxiety and biomarkers in adults with Parkinson’s disease (PD). Patients & methods: 16 adults ages 36–80with PD participated in the intervention for 12 weeks. The study provided pre-post-study comparisonsof biomarkers, weight, waist measurement, united Parkinson’s Disease Rating Scale (UPDRS), Parkinson’sAnxiety Scale (PAS) and Center for
Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated