January 2021

Feast then famine – how fasting might make our cells more resilient to stress

Fasting /

Intermittent fasting (also called alternate day fasting) has become a popular diet. In most versions of intermittent fasting, people fast or eat very little a few days each week and then eat normal amounts during the remaining days. Fasting is something that human beings have practiced throughout history, often out of circumstance rather than choice. Our […]

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Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Diet and Exercise /

As a member of the neurotrophin family, BDNF regulates many of the processes within neurogenesis, such as differentiation and survival. Although much more is known about the direct role that exercise and BDNF have on hippocampal neurogenesis in rodents, their corresponding cognitive benefits in humans will also be discussed. Specifically, what is known about exercise-mediated

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Hydrogen-rich water as a modulator of gut microbiota?

Anti-oxidants, Vitamins / Supplements / Nutraceuticals /

However, no well-powered multicentric trial evaluated the effectiveness of HRW consumption so far in common gastrointestinal diseases with gut flora scenario, including inflammatory bowel disease, irritable bowel syndrome, gastroenteritis and colitis of infectious origin. HRW might be an up-and-coming compound that might tune endogenous H2 homeostasis and modulate gut microbiota but it should still be perceived

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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota /

Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that

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Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson’s Disease

A-Synuclein /

In conclusion, SNCA transcripts showed a disease-specific increase in the brain and were diminished in blood of LBD patients. SNCAtv3 expression was decreased in early DLB and increased in early PD and could be a biomarker for early DLB diagnosis. CLICK TO REVIEW

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Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson’s Disease

A-Synuclein, Gut-Brain axis /

Background: Parkinson’s disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of α-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. Summary: Cumulative evidence implicates that

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The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

Autophagy, Mitochondria, Uncategorized /

The increased activity of mPTP in aging turns autophagy/mitophagy into a destructive process leading to cell aging and death. Several drugs and lifestyle modifications that enhance healthspan and lifespan enhance autophagy and inhibit the activation of mPTP. Therefore, elucidating the intricate connections between pathways that activate and inhibit mPTP, in the context of aging and

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Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain

Fecal Transplants (FMT), Gut-Brain axis /

We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.). CLICK TO REVIEW

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Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

A-Synuclein /

The glymphatic system is involved in clearance of metabolic byproducts such as amyloid-b from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings

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