Risk and protective factors of PD development may influence PD clinical features. This finding may represent the first step in the development of new preventive approaches able to delay disease onset and mitigate the extent of clinical manifestations. CLICK TO REVIEW
Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson’s disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The aim of this study was to investigate the protective mechanisms of HBOT on neurons and motor function in
Consumption of a novel prebiotic mixture rapidly impacted the intestinal microbiota (10 days), reduced the abundance of pro-inflammatory bacteria and promoted the growth of beneficial SCFA-producing bacteria. In addition, prebiotic consumption increased plasma SCFA levels, and improved markers of intestinal barrier integrity and brain health. This proof-of-concept study provides evidence for the importance of intestinal
Proof of Concept Study of Prebiotics to Modulate Gut Microbiome in Parkinson’s Disease Read More »
Growing evidences show that gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD) and the gut-brain axis can be promising target for the development of the therapeutic strategies for PD. Acupuncture has been used to improve brain functions and inflammation in neurological disorders such as PD, and to recover the gastrointestinal dysfunctions in
Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases
Research progress on the association of neurological disorders and periodontal diseases Read More »
New research on the connection between sleep and Parkinson’s disease is being hailed as a “first step” toward curing and preventing the condition, a brain disorder that causes uncontrollable movements. The research, led by the Parkinson’s Progression Markers Initiative, funded by The Michael J. Fox Foundation, is working to make a concrete connection between Parkinson’s and REM sleep
New research reveals sleep disorder may be linked to Parkinson’s Read More »
eople with rapid eye movement (REM) sleep behavior disorder act out their dreams. While sleeping safely in bed, for example, they might throw up their arms to catch an imaginary ball or try to run from an illusory assailant. Such actions are more than just a nuisance. People with the disorder have a 50% to 80% chance
Sleep disorder linked to neurodegeneration aim of NIH-funded grant Read More »
Microbial dysbiosis in the gut is associated withhuman diseases, and variations in mucus alter gut microbiota.Therefore, we explored the effects of mucin on the gut microbiotausing a community of 19 synthetic gut microbial species. Cultivationof these species in modified Gifu anaerobic medium (GAM)supplemented with mucin before synthetic community assemblyfacilitated substantial growth of the Bacteroides, Akkermansia,and
A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then
Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder Read More »
Accumulating evidence to date suggests that brown rice is superior to white rice in regards to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would