Vagal Nerve

Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

Dopaminergic cells, which use dopamine as a neurotransmitter, arenot as numerous as other brain nerve cells such as serotonergic andGABAergic neurons. However, dopamine neurons project to a varietyof important brain regions to control movement, emotion, the rewardsystem, and the secretion of prolactin. Both schizophrenia andParkinson’s disease are disorders of the dopaminergic neurotransmissions, but schizophrenia has […]

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Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Biomarkers, Constipation, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in

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Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Vagal Nerve /

There has been exponential growth in the awareness and understanding of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) over the past 3 decades. The clinical features of GI dysfunction in PD have been clearly identified and innovative research has demonstrated the presence of pathology within the enteric nervous system (ENS) in individuals with PD, leading

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Effect of vagotomy on modulation of dopaminergic neurons in Parkinson’s disease

A-Synuclein, Gut-Brain axis, Parkinson's Disease, Vagal Nerve /

Our results suggest that vagotomy has protective effects onnigrostriatal dopaminergic degeneration and disease progression insubsequent Parkinson’s disease, but may be unfavorable for cognitiveperformance. The neuroprotective effect of vagotomy could be largelymediated by blocking the spread of α-synuclein from the gut to the brain,and the modulation of inflammatory response might also contribute tosome extent. CLICK TO

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Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease

Gut-Brain axis, Lectins, Parkinson's Disease, Vagal Nerve /

Lectins from dietary plants have been shown to enhance drug absorption in the gastrointestinal tract of rats, be transported trans-synaptically as shown by tracing of axonal and dendritic paths, and enhance gene delivery. Other carbohydrate-binding protein toxins are known to traverse the gut intact in dogs. Post-feeding rhodamine- or TRITC-tagged dietary lectins, the lectins were

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease Read More »

Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

Fecal Transplants (FMT), Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Vagal Nerve /

In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways.

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The role of the host microbiome in autism and neurodegenerative disorders and effect of epigenetic procedures in the brain functions

Gut Dysbiosis, Gut-Brain axis, Vagal Nerve /

Autism Spectrum Disorder (ASD) is a severe neurological/neurodegenerative syndrome that results in cognitive and communication disorders. The degree of dysbiosis is related to the severity of ASD signs. The gut is conferred with a variety of sensory receptors that cooperate with effector systems including the endocrine, nervous and gut immune systems of the intestine. Gut

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Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axis

Detox, Endotoxin, Gut-Brain axis, Vagal Nerve /

Inflammasomes are multi-protein complexes expressed in immune cells that function as intracellular sensors of environmental, metabolic and cellular stress. Inflammasome activation in the brain, has been shown to drive neuropathology and disease progression by multiple mechanisms, making it one of the most attractive therapeutic targets for disease modification in Parkinson’s Disease (PD). Extensive inflammasome activation

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Microbiota in Health and Disease—Potential Clinical Applications

A-Synuclein, Butyrate, Diet and Exercise, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids, Vagal Nerve /

: Within the last two decades tremendous efforts in biomedicine have been undertaken tounderstand the interplay of commensal bacteria living in and on our human body with our ownhuman physiology. It became clear that (1) a high diversity especially of the microbial communitiesin the gut are important to preserve health and that (2) certain bacteria

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