Orthostatic Hypotension

Clinical and imaging evidence of brain-first and body-first Parkinson’s disease

A-Synuclein, Autonmic nervous system, Constipation, ENS, Gut Dysbiosis, iRBD, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Braak’s hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson’s disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to […]

Clinical and imaging evidence of brain-first and body-first Parkinson’s disease Read More »

Non-Motor Symptoms and Their Associated Factors in Parkinson’s Disease

Biomarkers, Constipation, Dreams, Non-Motor Symptoms, Orthostatic Hypotension /

Background: Parkinson’s disease is a common neurologic ailment that causes tremor and bradykinesia. The prevalenceof Parkinson’s disease is estimated to be 1–2 in 1000, affecting about 1% of the population over the age of 60 years. Theobjective of this study was to find the frequency of Non-Motor Symptoms in patients with Parkinson’s Disease (PD) andits

Non-Motor Symptoms and Their Associated Factors in Parkinson’s Disease Read More »

Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort

Biomarkers, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain

Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort Read More »

Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysis

A-Synuclein, Biomarkers, Hyposmia, Hyposmia, iRBD, Orthostatic Hypotension /

Background A number of promising biomarkers for predicting imminent α-synucleinopathies have been suggested in isolated rapid eye movement sleep behaviour disorder (iRBD). However, existing evidence is conflicting without quantitative evaluation. Methods PubMed, Web of Science and ClinicalTrials.gov were searched through June 2021 to identify possible predictors of phenoconversion from iRBD to Parkinson’s disease (PD). The pooled HRs

Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysis Read More »

Orthostatic Hypotension: JACC State-of-the-Art Review

Autonmic nervous system, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Neurogenic orthostatic hypotension is a highly prevalent and disabling feature of autonomic failure due to both peripheral and central neurodegenerative diseases. Community-based epidemiological studies have demonstrated a high morbidity and mortality associated with neurogenic orthostatic hypotension. It is due to impairment of baroreflex-mediated vasoconstriction of the skeletal muscle and splanchnic circulation and is caused by damage

Orthostatic Hypotension: JACC State-of-the-Art Review Read More »