Hydrogen

Composition of intestinal flora affects the risk relationship between Alzheimer’s disease/Parkinson’s disease and cancer

Gut Microbiota, Gut Permeability / Leaky Gut, Hydrogen, Parkinson's Disease, Pre-PD /

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer’s disease/Parkinson’s disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, […]

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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Biomarkers, Gut Dysbiosis, Gut Microbiota, Hydrogen, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are

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Design of synthetic human gut microbiome assembly and butyrate production

Butyrate, Hydrogen /

Guided by the model, we identify constraints on butyrate production by high species richness and key molecular factors driving butyrate production, including hydrogen sulfide, environmental pH, and resource competition. In sum, our model-guided approach provides a flexible and framework for understanding and accurately predicting community assembly and metabolic functions. CLICK TO REVIEW

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Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate

Butyrate, Gut Dysbiosis, Hydrogen /

Further experiments demonstrated that the beneficial effect of butyrate depended on the bacteria that colonized the gut and that this protective effect required SKN-1/Nrf2 and DAF-16/FOXO transcription factors. We also found that bacteria-derived protein aggregates contribute to the observed disruption of host proteostasis. Together, these results reveal the significance of enteric infection and gut dysbiosis

Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate Read More »