March 2022

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may […]

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Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Ayahuasca, Gut Microbiota /

There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection

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Gastrointestinal involvement in Parkinson’s disease: pathophysiology, diagnosis, and management

Biomarkers, Constipation, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease /

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract (GIT) dysfunction in Parkinson’s disease (PD). Most patients suffer from GIT symptoms, including dysphagia, sialorrhea, bloating, nausea, vomiting, gastroparesis, and constipation during the disease course. The underlying pathomechanisms of this α-synucleinopathy play an important role in disease development and progression, i.e., early accumulation

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Food as Treatment of Inflammatory Bowel Diseases

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota /

Inflammatory bowel diseases (IBD), namely, Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong and incurable chronic inflammatory diseases affecting6.8 million people worldwide. By 2030, the prevalence of IBD is estimated to reach 1%of the population in Western countries, and thus there is an urgent need to developeffective therapies to reduce the burden of this

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Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study

Diet and Exercise, Parkinson's Disease, Pre-PD /

The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson’s disease (pPD) probability and incidence among community-dwelling older individuals without clinical features of parkinsonism at baseline. More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older

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Identification of alpha-Synuclein Disaggregator from Camellia sp. Insight of Molecular Docking and Molecular Dynamics Simulations

A-Synuclein, Diet and Exercise /

Misfolded protein formation and aggregation are the central hallmarks for various neurodegenerative disorders. When it comes to Parkinson’s disease (PD), alpha-synuclein (α-syn) is the culprit protein. The presence of α-syn protein in lewy bodies and lewy neurites confirmed its presence in the occurrence of PD. The protein is natively present in the soluble monomeric forms,

Identification of alpha-Synuclein Disaggregator from Camellia sp. Insight of Molecular Docking and Molecular Dynamics Simulations Read More »

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice

Butyrate, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice Read More »

Roles of oral microbiota and oral-gut microbial transmission in hypertension

Gut-Brain axis, Oral Microbiome, Periodontitis /

Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered. CLICK TO REVIEW

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Dual role of the nasal microbiota in neurological diseases—An unignorable risk factor or a potential therapy carrier

Gut Dysbiosis, Mitochondria, Olfactory, Parkinson's Disease /

Recently, comparative studies have rapidly increased with the closer correlation between microbiota and neurological diseases. However, most insights about the association between microbiota and neurological diseases still focus on the gut-brain axis and ignore that nasal microbiota could form a complex and essential link with the nervous system via the nose-to-brain pathway, suggesting the role

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Metagenomic and Functional Characterization of Two Chilean
Kefir Beverages Reveals a Dairy Beverage Containing Active
Enzymes, Short-Chain Fatty Acids, Microbial β-Amyloids,
and Bio-Film Inhibitors

Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

: Kefir beverage is a probiotic food associated with health benefits, containing probioticmicroorganisms and biomolecules produced during fermentation. The microbial compositionof these beverages varies among countries, geographical regions, and the substrates, therefore,the characterization of kefir beverages is of great relevance in understanding their potential healthpromoting and biotechnological applications. Therefore, this study presents the metagenomic andfunctional

Metagenomic and Functional Characterization of Two Chilean
Kefir Beverages Reveals a Dairy Beverage Containing Active
Enzymes, Short-Chain Fatty Acids, Microbial β-Amyloids,
and Bio-Film Inhibitors Read More »