Zonulin

Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease

A-Synuclein, Fecal Transplants (FMT), Gut Dysbiosis, Olfactory, Vagal Nerve, Zonulin /

Parkinson’s disease (PD) is characterized by alpha-synuclein misfolding with subsequent intraneuronal amyloid formation and accumulation, low grade neuroinflammatory changes, and selective neurodegeneration. Available evidence suggests that thepathology usually begins in the gut and olfactory mucosa, spreading to the brain via the vagus and olfactory nerves, by a prion-like mechanism. A causal relationship has not been […]

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Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study

Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD, Zonulin /

Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin may aid in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases. CLICK TO REVIEW

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Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids, Zonulin /

Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate

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