January 2021

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics

Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Pre-clinical and human clinical trial data reveal exciting potential for novel treatment targets and therapeutic modulation with prebiotics, medicinal herbs, probiotics, and synbiotics in health, aging, and neurodegeneration and are reviewed here. While greater insights and characterization of the microbiota-gut-brain axis have been revealed over the past decade, salient questions related to the pathology, pathogenesis […]

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics Read More »

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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High intensity aerobic exercise improves information processing and motor performance in individuals with Parkinson’s disease

Diet and Exercise /

The improvement in information processing following aerobic exercise, but not levodopa administration, suggests high intensity exercise may be enhancing neural processing and non-motor pathways outside those impacted by medication. The persistence of symptom improvement despite exercise intervention cessation indicates exercise is a candidate for disease modification.  CLICK TO REVIEW

High intensity aerobic exercise improves information processing and motor performance in individuals with Parkinson’s disease Read More »

Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway

Anti-oxidants, Butyrate, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Ochratoxin A (OTA) is a common environmental pollutant found in a variety of foods and grains, and excessive OTA consumptioncauses serious global health effects on animals and humans. Astaxanthin (AST) is a natural carotenoid that has anti-inflammatory,antiapoptotic, immunomodulatory, antitumor, antidiabetes, and other biological activities. The present study is aimed atinvestigating the effects of AST on

Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway Read More »

Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols

Diet and Exercise, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Neurodegenerative diseases are becoming a big challenge for modern society. Neurodegenerative disorders strongly impact on patient and their caregivers. Moreover, since the population is becoming older, these pathologies will deeply influence medical and socio-economic conditions in the next years. CLICK TO REVIEW

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Unmet needs in Parkinson disease: Motor and non-motor

Pre-PD, Symptoms / Diagnosis /

Characterizing the clinical phenotype of the entire non-motor profile of PD is challenging. Further research and understanding are needed for discovering biomarkers of certain NMS, such as dementia, fatigue, pain, sleep, and apathy. More work is needed to gather a robust evidence base for guiding treatment of troubling NMS, which exert a major impact on

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The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?

Probiotics, Prebiotics and Symbiotics /

This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy, confirming that gut microbiota modulation influences different pro-survival pathways. Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. CLICK TO REVIEW

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Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation

Anti-oxidants, Vitamins / Supplements / Nutraceuticals /

Oxidative stress is highlighted as an important factor in the genesis of PD, involving several enzymes and signaling molecules in the underlying mechanisms of the disease. This review presents updated data on the involvement of oxidative stress in the disease, as well as the use of antioxidant supplements in its therapy CLICK TO REVIEW

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