January 2021

Faecal Transplantation, Pro- and Prebiotics in Parkinson’s Disease; Hope or Hype?

A-Synuclein, Fecal Transplants (FMT), Probiotics, Prebiotics and Symbiotics /

. Faecal microbiome transplantation (FMT) is an attractive technique, because the administration is relatively simpleand in general has a mild adverse effect pattern. Moreover, FMT consists of a broad mixture, which could be beneficial,because at this moment it is not known what type of changes in the microbiome are needed. However, except from a fewcases […]

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Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson’s Disease

Gut Microbiota, Short Chain Fatty Acids /

Increasing evidence is supporting the hypothesis of -synuclein pathology spreading from the gut to the brainalthough the exact etiology of Parkinson’s disease (PD) is unknown. Furthermore, it has been proposed that inflammation,via the gastrointestinal tract, potentially through infections, may contribute to -synuclein pathogenesis, and thus to the riskof developing PD. CLICK TO REVIEW

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Fecal transplants as a microbiome-based therapeutic

Fecal Transplants (FMT), Therapies /

Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance patients’ microbiomes. Recent evidence has demonstrated that bacterial and viral richness, short

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COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D

Virus /

We previously reported a north–south gradient in global COVID-19 mortality but were conscious that lack of ultraviolet exposure and consequent vitamin D insufficiency was not the only possible explanation. We have now investigated the relationships between latitude, age of population, population density and pollution with COVID-19 mortality   CLICK TO REVIEW

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SARS-CoV-2 positivity rates associated with
circulating 25-hydroxyvitamin D levels

Virus /

Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity

SARS-CoV-2 positivity rates associated with
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A rapid a-synuclein seed assay of Parkinson’s disease CSFpanel shows high diagnostic accuracy

Biomarkers /

Assays that specifically measure a-synuclein seeding activity inbiological fluids could revolutionize the diagnosis of Parkinson’s disease. Recentimprovements in a-synuclein real-time quaking-induced conversion assays ofcerebrospinal fluid have dramatically reduced reaction times from 5-13 daysdown to 1-2 days.    Click here for report

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A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy

Biomarkers, Library, Parkinson's Disease /

Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson’s disease while maintaining the high-performance standards associated with previous α-synuclein seed assays, supporting the clinical utility of this assay for Parkinson’s disease diagnosis.  https://doi.org/10.1002/acn3.51280

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