REM sleep behaviour disorder overwhelmingly affects males older than 50 years, but increasingly this disorder is being identified in females and in younger individuals. Symptoms in young individuals, particularly young females, should raise the possibility of narcolepsy or medication-induced REM sleep behaviour disorder. CLICK TO REVIEW
Rapid Eye Movement (REM) Sleep Behavior Disorder Read More »
In addition, in vitro and in vivo studies have shown that cinnamon extracts may affect the oligomerization process and aggregation of α‐synuclein. Herein, we discuss recent evidence on the novel therapeutic opportunities of this phytochemical against PD, indicating additional mechanistic aspects that should be explored, and potential obstacles/limitations that need to be overcome, for its
Compared with patients without OH, patients with DOH had severe hyposmia. Relatively preserved peripheral sympathetic nervous system function in patients with DOH suggests that DOH might be an early and milder form of OH in PD. CLICK TO REVIEW
In conclusion, the present study demonstrates the power of using multi-omics molecular profiling to reveal changes in the gut microbiome and serum biochemistry following exposure to chemical pollutants that would otherwise be missed using more standard, less comprehensive analytical methods. Employing this approach allowed us to identify glyphosate effects on the rat gut microbiota, namely
The presence of olfactory dysfunction conveys a considerably elevated risk of incident PD, likely more in studies with a higher proportion of women, older individuals or short follow-up duration. Individual patient data are warranted to confirm these findings and to yield subgroup-specific risk estimates of other common markers to refine prodromal PD criteria. CLICK TO
The improvements in SVaD-IF mice suggest that IF could be a potential nonpharmacological remedy for SVaD. This finding could stimulate future investigations on IF’s neuroprotective potential across many neurovascular diseases. CLICK TO REVIEW
Connectomic approaches reveal a number of hubs in the olfactory system (anterior olfactory nucleus, olfactory entorhinal cortex and cortical amygdala) that are key interconnectors with the main hubs (the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus) of network dysfunction in Alzheimer’s and Parkinson’s diseases. CLICK TO REVIEW
The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases Read More »
This review will focus on the most promising marine drugs’ neuro-protective potential for neuro-degenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neuro-degenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. CLICK TO REVIEW
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders Read More »
The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neu-roprotective effects, particularly in the Lachnospiraceae family and key members,such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, andBlautia. The direct evalua-tion of fecal metabolites revealed changes in several classes of metabolites. Changeswere seen in lipids (linoleic acid, oleic acid,
Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease Read More »
There is a bidirectional communication between the brain and the gut called “gutmicrobiota-brain axis (GMBA)” and its dysfunction causes numerous diseases. This review focuses on theinter-relationship between the gut microbiome and the Parkinson’s disease.(4) (PDF) Interrelationship between Gut microbiota and Parkinson’s disease. Available from: https://www.researchgate.net/publication/346456083_Interrelationship_between_Gut_microbiota_and_Parkinson’s_disease [accessed Jan 31 2021].
Interrelationship between Gut microbiota and Parkinson’s disease Read More »