March 2021

Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Fasting, Iron /

Eight days of total starvation diet affected the body composition and decreased exercise capacity. Further, fasting decreased the expression of genes associated with iron storage and export, and increased the expression of genes involved in iron acquisition. Conversely, only PCBP2 protein increased after fasting; however, an upward trend was apparent for all proteins. In conclusion, […]

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Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

Iron, Parkinson's Disease, Pre-PD /

The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+, implicating a critical increase in the labile iron pool. Indeed, neuromelanin is characterized by a significantly higher loading of iron including most probable the occupancy of low-affinity iron binding sites. Quantitative trace element analysis is

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The cell biology of Parkinson’s disease

A-Synuclein, Parkinson's Disease /

Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in its rare, inheritable forms, termed PARK genes. These genes encode proteins including α-syn, LRRK2, VPS35, parkin, PINK1, and DJ1, which can

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Biomarkers and the Role of α-Synuclein in Parkinson’s Disease

A-Synuclein, Biomarkers, Pre-PD /

This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to monitor disease progression. This review article describes the role of α-Syn in PD and how it could potentially be used as a biomarker for PD. Also, preclinical and clinical investigations encompassing genetics, immunology, fluid and

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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Pre-PD /

These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Biomarkers, Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Gut-Brain axis /

The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

A-Synuclein, Biomarkers, Pre-PD /

Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that impair neuronal function. The resultant synaptopathy causes behavioural deficits and progressive age-related neurodegeneration. Thissuccession of phenotypes recapitulates key events of dying-back like neurodegeneration5,27,92 and provide insights into the pathogenic mechanisms underlying synaptopathy, the likely initiating

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Nutritional aspects in Parkinson’s disease

Biomarkers, Diet and Exercise, Parkinson's Disease, Pre-PD /

The links between diet and Parkinson’s disease (PD) are unclear and incomprehensible. However, numerous studies have demonstrated the correlation between diet, nutrients and health condition in PD patients. They indicate the possibility of management of the disease, which might be possible through nutrition. Pharmaceutical treatment as well as a complementary holistic approach to the patients

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PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort (PPMI)

Biomarkers, iRBD, Symptoms / Diagnosis /

The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson’s disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls The overall goal of PPMI 2.0 is to identify

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