March 2021

An Overview of Alpha Synuclein Protein and Its Role in Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Uncategorized /

Under pathologic conditions, cellular accumulation of misfolded α-synuclein oligomers and aggregates are observed in a group of neurodegenerative diseases called synucleinopathies. The mechanisms of how α-synuclein protein takes part in the neurodegeneration process and physiologic roles of the protein have not been fully elucidated yet. It’s important to unravel the secrets of this protein and […]

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The gut microbiota metabolite propionate ameliorates intestinal epithelial barrier dysfunction-mediated Parkinson’s disease via the AKT signaling pathway

Biomarkers, Butyrate, Gut Microbiota, Short Chain Fatty Acids /

Our results demonstrated that propionate, which was decreased in the fecal samples of Parkinson’s disease patients, exerted beneficial effects on intestinal epithelial barrier function and improved motor behavior in MPTP-induced Parkinson’s disease mice through the AKT signaling pathway. CLICK TO REVIEW

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Autonomic disorders predicting Parkinson disease

Biomarkers, Constipation, iRBD, Pre-PD /

There is evidence that constipation, urinary and sexual dysfunction and more recently decreased cardiac chronotropic response during exercise, are part of the premotor parkinsonian phenotype. The sensitivity and specificity of these features has yet to be accurately assessed. We briefly review the evidence for autonomic dysfunction as biomarker of premotor PD. CLICK TO REVIEW

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The microbiota–microglia axis in central nervous system disorders

Biomarkers, Butyrate, Gut Microbiota, Pre-PD, Short Chain Fatty Acids /

Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids (SCFAs) or aryl hydrocarbon receptor (AhR) ligands. Thereby, the gut microorganisms are deemed to influence numerous CNS diseases mediated by microglia.In this review, we summarize recent findings of the interaction between the host microbiota and

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Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder

Biomarkers, iRBD, Pre-PD /

The iRBD patients had increased classical monocytes and mature natural killer cells. Remarkably, the levels of expression of Toll-like receptor 4 (TLR4) on blood monocytes in iRBD patients were positively correlated with nigral immune activation measured by 11C-PK11195 PET and negatively correlated with putaminal 18F-DOPA uptake; the opposite was seen for the percentage of CD163+

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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health

Biomarkers, Diet and Exercise, Gut Microbiota, Gut-Brain axis, Short Chain Fatty Acids /

Animal studies investigating the potential of nutritional interventions on the microbiota–gut–brain axis have led to advancements in our understanding of the role of diet in this bidirectional communication. In this review, we summarize the current state of the literature triangulating diet, microbiota, and host behavior/brain processes and discuss potential underlying mechanisms. Additionally, determinants of the

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Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early

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MDS research criteria for prodromal Parkinson’s disease

Biomarkers, Pre-PD /

 This diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker testing. In order to be included, diagnostic markers had to have prospective evidence documenting ability to predict clinical PD. They include motor and nonmotor clinical symptoms, clinical signs, and ancillary diagnostic tests. These criteria represent

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Recent advances and health implications of dietary fasting regimens on the gut microbiome

Fasting, Gut Microbiota /

Although the number of preclinical and clinical interventions are limited, significant data thus far suggest fasting interventions impact GM composition and physiology. However, there are considerable heterogeneities of study design, methodological considerations, and practical implications. Ongoing research on the health impact of fasting regimes on GM modulation is warranted. CLICK TO REVIEW

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