March 2021

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids, Zonulin /

Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate […]

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Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder

A-Synuclein, iRBD, Pre-PD /

We found abnormal ECN and normal DMN as a possible hallmark of cognitive dysfunctions in early α-synucleinopathies. We replicated abnormalities in BGN and SMN corresponding to subclinical movement disorder of RBD. RsfcMRI may provide an early biomarker of both cognitive and motor network dysfunctions of α-synucleinopathies. CLICK TO REVIEW

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Altered Functional Connectivity Between Insula and Precuneus in Isolated REM Sleep Behavior Disorder

Biomarkers, iRBD /

Connectivity between the insula and precuneus may be associated with cognitive function among patients with isolated rapid eye movement sleep behavior disorder (iRBD), according to the results of a cross-sectional study published in Sleep Medicine. Study researchers recruited patients (n=50) diagnosed by video-polysomnography with iRBD at Seoul National University Hospital Sleep Clinic and healthy controls (n=20)

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Predicting Parkinson’s Disease Trajectory using Clinical and Neuroimaging Baseline Measures

Biomarkers /

Predictive biomarkers of Parkinson’s Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work uses measures derived from resting-state functional magnetic resonance imaging, including regional homogeneity (ReHo) and fractional amplitude of low frequency fluctuations (fALFF), to predict an individual’s current and future severity over up to 4 years and to elucidate

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Non-negative matrix factorization-based time-frequency feature extraction of voice signal for Parkinson’s disease prediction

Biomarkers, dysarthria /

The proposed method achieved average classification accuracies of up to 92 % in vowels, and 97 % in words. There is an improvement in accuracy ranging from 10% to 40 % compared to existing methods. Further, the developed models are evaluated upon an independent dataset. Results on this separate test set show accuracies ranging from

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Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Metabolites, Pre-PD, Short Chain Fatty Acids /

We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as

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Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders

Gut Dysbiosis, Gut Microbiota, Vagal Nerve /

The microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central nervous system. While the MGBA plays a pivotal role in normal development and physiology of the nervous and gastrointestinal system of the host, its dysfunction has been strongly implicated in neurological disorders, where intestinal dysbiosis

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Lipopolysaccharides (LPS), Probiotics, Prebiotics and Symbiotics /

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut

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The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease

A-Synuclein, Biomarkers, Pre-PD /

This review aims to provide an insight into the current literature concerning salivary biomarkers used in the diagnosis of AD and PD. The most commonly studied salivary biomarkers in AD are β-amyloid1-42/1-40 and TAU protein, as well as α-synuclein and protein deglycase (DJ-1) in PD. Studies continue to be conducted on this subject and researchers

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