The gut microbiome shifted among individuals with constipation and PD after four weekly treatments with the OMM-sequence. Changes in the gut microbiome Post-OMM were associated with UPDRS results and constipation measures. Clinical trials and studies to develop the gut microbiome into a validated biomarker for PD are necessary to understand the impact of OMM in […]
Parkinson’s disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes. However, its pathological mechanism remains undetermined. Accumulating evidence has revealed the emerging functions of gut microbiota and microbial metabolites, which can affect both the enteric nervous system and the central nervous system via the microbiota-gut-brain axis. Accordingly, intestinal dysbiosis might be closely associated
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease Read More »
Finally, the pros and cons of the current treatments for PD, including those targeting microbiota, are assessed. Advancements in research techniques, further studies on levels of specific strains and longitudinal prospective clinical trials are urgently needed for the identification of early diagnostic markers and the development of novel therapeutic approaches for PD. CLICK TO REVIEW
I find this article to be quite interesting as they author finds no relationship between dreams and food. This researcher (me) has found a connection not just between dreams and food but dreams, gluten, lectins, dairy and dream enactments. Science is missing just how toxic our food supply is and how directly connected it could
Do Certain Foods Really Cause Bad Dreams? Read More »
We found that PM2.5 were associated with increased risk of incident PD while surrounding green was associated with decreased risk of PD. Future studies about PD etiology may benefit from including multiple environmental exposures to address potential joint associations. CLICK TO REVIEW
The Michael J. Fox Foundation (MJFF) devotes our donor-raised dollars to the most promising scientific efforts to bring new treatments and cures closer to patient hands. In February and March, MJFF funded 56 new grants totaling nearly $19 million. https://www.michaeljfox.org/news/what-we-fund-19-million-advance-new-therapies-and-study-environmental-risks?em_cid=mc-a1b1R00000A5RyQ&et_cid=1855890&et_rid=574902244&et_lid=http%3a%2f%2fwww.michaeljfox.org%2fnews%2fwhat-we-fund-19-million-advance-new-therapies-and-study-environmental-risks%3fem_cid%3dmc-a1b1R00000A5RyQ
What We Fund: $19 Million to Advance New Therapies and Study Environmental Risks Read More »
Parkinson’s disease is a progressive disease of the brain caused by the death of special nerve cells. The disease is characterized by movement disorders such as slowing movements, stiffness of the muscles, tremors or specific changes in the gait pattern. Often there can be many years before these typical symptoms permit a diagnosis of Parkinson’s disease. These can
Parkinson’s is announced long before the diagnosis Read More »
The search for therapeutic targets for Parkinson’s disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous system are incompletely understood. Multiple lines of evidence suggest that the gut microbiota participates
Dermal p-syn in iRBD is most probably an early consistent marker of synucleinopathy and may support other indicators of conversion to manifest disease state. CLICK TO REVIEW
Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged
Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology Read More »