Communication between the GI tract and the CNS occurs via the neuronal,endocrine, and immunological pathways through a) the production of neurotransmitters, b) the tryptophan metabolism, c) the modulation of the immunological activity in the CNS and the SNE, d) production of short chain fatty acids, e) the production of intestinal hormones, and f) the production […]
Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and Huntington’s disease (HD). Consequently, the analysis indicates that polyphenol beneficial effects on human brain activity and this review describe these implications by discussing the latest mechanistic hypothesis. CLICK TO
Natural polyphenols in central nervous system disorders Read More »
Exposure to mycotoxins can lead to acute as well as chronic toxic effects, which are dependent on the mycotoxin type, the amount, length of the exposure, and the health, age, and sex of the patient. Dietary deficiency, co-existing health conditions, and environmental/chemical exposure potentially create a compounding effect which can impact the severity of symptoms.
At 12 weeks post-injection, a separate 43 and distinct pattern of structural and sensory-evoked functional brain activity changes was 44 observed that are co-localized with previously reported regions of α-syn pathology and immune 45 activation. Microstructural changes in the pons at 12 weeks post-injection were found to predict 46 survival time and preceded measurable locomotor
Visuomotor activity during visually-guided pinch-grip force was measured while controlling for force without visual feedback activity and visual stimuli without force activity in healthy adults. Using physiological noise correction and multiple task repetitions, we demonstrated that visuomotor activity occurs in the inferior portion of the basilar pons and the midbrain. These findings provide direct evidence
Early and untreated PD patients showed irregular EGG waves and high ICDF. EGG showed better accuracy than the olfactory test for early PD diagnosis and similar sensitivity to MIBG scintigraphy. CLICK TO REVIEW
In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or its interaction with aging, will aid in the development of safe and optimized therapeutic approaches for remodeling the parkinsonian striatum. CLICK TO REVIEW
There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to initiate the free radical formation and affecting the basal ganglia signaling. In this review, we explored how these metals affect brain physiology and their roles in the accumulation of toxic proteins (α-synuclein and Lewy bodies).
This review provides an overview of the current knowledge of these effects, with specific focus on energy metabolism, intestinal barrier, immune system, and disease activity in IBD. To conclude, more research is needed on the cross-feeding mechanisms in the gut microbiome, as well as on the therapeutic potential of SCFAs on different disease models. Also
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? Read More »
Overall, our data suggested that β-glucan could be completely hydrolyzed by human fecal microbiota but not thoroughly degraded by mice fecal microbiota. The notion shed some light on the effect of gut microbial source on β-glucan degradation, providing new information for the relationship between β-glucan metabolism and gut microbiota. CLICK TO REVIEW