April 2021

Complications following REM sleep behavior disorder

iRBD, Parkinson's Disease, Pre-PD /

REM sleep behavior disorder (RBD) is gaining increasing attention as important prodromal marker for the development of neurodegenerative disorders such as Parkinson’s Disease. However, the clinical relevance of this disorder and its association with other prodromal markers is often underestimated in clinical routine. We here report a case of severe clinical complications following extensive nocturnal […]

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The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy

Autophagy, Gut Dysbiosis, Gut-Brain axis, Vagal Nerve /

Hence, this review will mainly focus on analysing the basic components of the gut that might be responsible for aggravating lewy pathology, the mediator(s) responsible for transmission of PD pathology from gut to brain and the important role of trehalose in ameliorating gut dysbiosis related PD complications that would eventually pave the way for therapeutic

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Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease

Autophagy, Parkinson's Disease, Pre-PD /

Hence, autophagy modulation might provide some interesting cues for the treatment of PD. Additionally, Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective in various neurodegenerative conditions possibly via mediation of autophagy. CLICK TO REVIEW

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Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Herbs & Spices, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

After in vitro digestion and anaerobic fermentation, both O. sinensis and C. militaris could modulate the gut microbiota composition through reducing the ratio of Firmicutes to Bacteroidetes. Moreover, this research demonstrated that O. sinensis had more positive effects on the intestinalhealth compared with C. militaris via decreasing the pH of gut environment, stimulating the production

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Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Diet and Exercise, Parkinson's Disease, Therapies /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from

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Is Chelation Therapy a Potential Treatment for Parkinson’s Disease

Iron, Parkinson's Disease /

The current use of chelators in clinical medicine is presented together with a discussion of two clinical trials of PD patients where an iron chelator was administered and showed encouraging results. It is proposed that the use of anti-inflammatory drugs combined with an iron chelator might be a better approach to increase chelator efficacy. CLICK

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Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease

A-Synuclein, Parkinson's Disease /

In this Review, we summarize the structure and physiological function of α-syn, and we further highlight the major PTMs (namely phosphorylation, ubiquitination, nitration, acetylation, truncation, SUMOylation, and O-GlcNAcylation) of α-syn and the effects of these modifications on α-syn aggregation, which may elucidate mechanisms for PD pathogenesis and lay a theoretical foundation for clinical treatment of

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Dietary Influences on the Microbiota–Gut–Brain Axis

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Finally, we should revise our view of the gut microbiota from that of a seething mass of microbes to one of organ-status, on which our health and wellbeing utterly depends. Future guidelines on lifestyle strategies for wellbeing should integrate advice on the optimal establishment and maintenance of a healthy gut microbiota through dietary and other

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