May 2021

The Potential Role of Cinnamon in Human Health

Parkinson's Disease, Pre-PD /

In folk medicine, cinnamon species have been used as medicine for respiratory and digestive disorders. Their potential for prophylactic and therapeutic use in Parkinson’s and Alzheimer’s disease has also been discovered. This review summarizes the available isolation methods and analytical techniques used to identify biologically active compounds present in cinnamon bark and leaves and the […]

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Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy

A-Synuclein, Dementia - Lewy Bodies, Diet and Exercise, iRBD, Pre-PD /

The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with

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Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression of LTS in iRBD patients. Our data also indicate that profiling of serum samples by NMR may be a useful tool for identifying short-term high-risk iRBD patients for conversion to parkinsonism or dementia. CLICK TO

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Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Supplementation of regular diet with medium-chain triglycerides for neuroprotective effects

Diet and Exercise, Short Chain Fatty Acids /

This review summarizes currently available research on the effects and revealed mechanisms of using MCTs as a supplement to standard feed/diet without concomitant reduction of carbohydrate intake, highlighting open questions and potential considerations.

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Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Diseases: a Mendelian Randomization Study

Metabolites /

Our findings provided robust evidence supporting causal effects of circulating glycoprotein acetyls, ApoB, LDL cholesterol, and serum total cholesterol on higher risk of AD, whereas glutamine showed the protective effect. Further research is required to decipher the biological pathways underpinning associations. CLICK TO REVIEW

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurological disorders, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, and neuromyelitis optica spectrum disorders, among others. This review will discuss the current evidence from the most significant studies dealing with some SCFAs from gut microbial metabolism with selected neurological disorders. CLICK

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Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate

Butyrate, Gut Dysbiosis, Hydrogen /

Further experiments demonstrated that the beneficial effect of butyrate depended on the bacteria that colonized the gut and that this protective effect required SKN-1/Nrf2 and DAF-16/FOXO transcription factors. We also found that bacteria-derived protein aggregates contribute to the observed disruption of host proteostasis. Together, these results reveal the significance of enteric infection and gut dysbiosis

Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate Read More »

Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides

Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Inulin and GOS diets were associated with increased butyrate production and better anastomotic healing. Histological analysis revealed an enhanced mucosal continuity, and this was associated with an increased re-epithelialization of the wound as determined by increased epithelial proliferation. Collagen concentration in peri-anastomotic tissue was higher with inulin and GOS diets and MMP activity, a marker

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Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats

Butyrate, Gut Dysbiosis, Gut-Brain axis, Short Chain Fatty Acids /

Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system may play a role in the regulation of intestinal functions. Colonic permeability and visceral sensation was evaluated in rats. Septic

Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats Read More »