September 2021

Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

There is sufficient evidence to support vitamin D’s noncalcemic effects and the role ofvitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluatewhether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects(HS), multiple system atrophy (MSA) and Parkinson’s disease (PD) […]

Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients Read More »

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

Biomarkers, Parkinson's Disease, Pre-PD /

There are currently no consistent radiological findings for MPS, and pathological studies have shown that MPS, at least in the oldest old, are often underpinned by mixed neuropathologies, including those associated with Alzheimer’s disease, cerebrovascular disease, nigral neuronal loss, and Lewy bodies. Different subcategories of MPS appear to convey varying risk and specificity for PD

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations Read More »

Mitochondrial Dysfunction in a Mouse Model of Prodromal Parkinson’s Disease: A Metabolomic Analysis

Biomarkers, Mitochondria, Parkinson's Disease, Pre-PD /

For the development of disease-modifying therapies for Parkinson’s disease (PD) the identification of biomarkers in the prodromal stage is urgently required. Because PD is considered a systemic disease even in the early stage, we performed a metabolomic analysis of the plasma from a mouse model of prodromal PD (p-PD). Increased levels of isobutyrylcarnitine in p-PD

Mitochondrial Dysfunction in a Mouse Model of Prodromal Parkinson’s Disease: A Metabolomic Analysis Read More »

Calcium channels and iron metabolism: A redox catastrophe in Parkinson’s disease and an innovative path to novel therapies?

Iron, Parkinson's Disease, Pre-PD /

Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson’s disease (PD). However, the molecular mechanism involved remains unclear and critical to decipher for designing new PD therapeutics. The long-lasting (L-type) CaV1.3 voltage-gated calcium channel is expressed at high levels amongst nigral neurons of the

Calcium channels and iron metabolism: A redox catastrophe in Parkinson’s disease and an innovative path to novel therapies? Read More »

Advances in early predictors for phenotypic transformation of idiopathic rapid eye movement sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Pre-PD /

Idiopathic rapid eye movement (REM) sleep behavior disorder is recognized as a prodromal stage of α-synucleinopathies such as Parkinson′s disease, Lewy body dementia and multiple system atrophy. It is important to timely identify early predictors that can predict early conversion into α-synucleinopathies. This review provided an update on classic and novel early predictors of α-synucleinopathies in patients with idiopathic REM sleep behavior disorder and provided a comprehensive understanding on the phenotypic transformation of the disease. CLICK TO

Advances in early predictors for phenotypic transformation of idiopathic rapid eye movement sleep behavior disorder Read More »

Heat Shock Proteins, Sauna, and Global Health Benefits

A-Synuclein, Parkinson's Disease /

What are Heat Shock Proteins? When cells are exposed to stressful situations, they respond by creating heat shock proteins. Since the first type of stress found to activate these proteins was heat, the proteins were named heat shock proteins.  Other triggers of heat shock proteins in the body include cold temperatures, ultraviolet light, heavy metals,

Heat Shock Proteins, Sauna, and Global Health Benefits Read More »

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

A-Synuclein, Biomarkers /

The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing this gap we might improve our understanding of proteinopathic disorders that predominate in one sex. Therefore, we exposed male or female primary hippocampal cultures to preformed α-synuclein fibrils in a

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy Read More »

Parkinson’s disease outside the brain: targeting the autonomic nervous system

A-Synuclein, Parkinson's Disease /

Patients with Parkinson’s disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor deficits. This dysregulation might reflect early pathology and therefore could be targeted for the development of prodromal or diagnostic biomarkers. Only a few objective clinical tests assess disease progression and are used to

Parkinson’s disease outside the brain: targeting the autonomic nervous system Read More »

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Gut Dysbiosis /

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut microbiota and the brain via immune, circulatory and neural pathways, termed the Gut-Brain Axis (GBA). Alterations in gut microbiota composition, such as seen with an

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle Read More »

Recent aspects of ketogenic diet in neurological disorders

Diet and Exercise /

The ketogenic diet (KD) is a high-fat, low-carbohydrate diet, in which fat is used as the primary energy sourcethrough the production of ketone bodies (KBs) in place of glucose. The KD was formally introduced in 1921 tomimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatricepilepsy in the mid-1990s.

Recent aspects of ketogenic diet in neurological disorders Read More »