Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease. The purpose of this study was to investigate the link between microbiota composition in important mucosal interfaces (oral, nasal, and intestinal) and PD. Sequencing was undertaken of the V4–V5 region of the 16S ribosomal RNA (rRNA) gene of the microbiome from the oral cavity, […]
Oral, nasal, and gut microbiota in Parkinson’s disease Read More »
Parkinson‟s disease (PD) is the second most common neurodegenerative disease after Alzheimer‟sdisease and affects ~1% of the population over the age of 60 years in industrialised countries. Theaim of this review is to examine nutrition in PD across three domains: dietary intake and thedevelopment of PD; whole body metabolism in PD; and the effects of
Parkinson’s disease: the nutrition perspective Read More »
Alzheimer’s disease (AD) is a neurodegenerative disease that inevitably results in dementia and death. Currently, there are no pathogenetically grounded methods for the prevention and treatment of AD, and all current treatment regimens are symptomatic and unable to significantly delay the development of dementia. The accumulation of β-amyloid peptide (Aβ), which is a spontaneous, aggregation-prone,
Thoughts – Just maybe we are finding the mechanics behind the 2+ theory of PD which states that 2 or more variables must come about in order PD to progress into diagnosisable PD. Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble
I find this article from 2015 as the industry was very concerned regarding the reemergence of the “focal infection theory” (FIT). One must note that the origins of the FIT date all the way back to Socrates – yes pre-Jesus the Greeks knew of the connection between bad teeth and disease. This artcle was published
Endodontic infections and systemic health – where should we go? Read More »
Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease among olderadults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons of thesubstantia nigra pars compacta and the widespread accumulation of misfolded intracellularα-synuclein (α-syn). Genetic mutations and post-translational modifications, such as α-syn phosphorylation, have been identified among the multiple factors supporting α-syn accrual
The neuropeptide substance P (SP) plays an important role in neurodegenerative disorders, among which Parkinson’s disease (PD). In the present work we have reviewed the involvement of SP and its preferred receptor (NK1-R) in motor and non-motor PD symptoms, in both PD animal models and patients. Despite PD is primarily a motor disorder, non-motor abnormalities,
What Substance P might tell us about the Prognosis and Mechanism of Parkinson’s Disease? Read More »
The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system
Gut Microbiome and Alzheimer’s Disease Read More »
Objectives: The objective of this study was to introduce the evidence obtained throughextensive research that periodontitis increases risk of many systemic diseases. Method: Analysis of some oral bacteria (P. gingivalis, T. denticola, T. forsythia, A.actinomycetemcomitans, and F. nucleatum) and its related treatments and mediatorsby the specific methods (western blot, ELISA, etc). Results: This article reviews
The pathogenic mechanism of oral bacteria and treatment with inhibitors Read More »
Alpha-synuclein protein is associated with Parkinson’s disease and is an intrinsically disordered protein (IDP) in solution. The protein consists of three domains: N-terminal domain, NAC domain, and C-terminal domain. In this research, I used the Gaussian accelerated Molecular Dynamics (GaMD) simulations to examine the role of the flanking domains of the protein. My data show
PROTECTIVE ROLE OF THE FLANKING DOMAINS AND MEMBRANE SELECTIVITY IN THE ALPHA-SYNUCLEIN Read More »