Bacterial metabolites/proteins can also reduce ɑ-synuclein aggregation in vitro CLICK TO REVIEW POSTER
Strain-level meta-analysis of Parkinson’s disease-associated gut microbiome Read More »
The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch
Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study Read More »
Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM)sleep behavior disorder (RBD). Although there are current American Academy of SleepMedicine standards to diagnose RBD, several aspects need to be addressed to achieveharmonization across sleep centers. Prodromal RBD is a stage in which symptoms andsigns of evolving RBD are present, but do not yet meet
In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways.
Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear.
Melatonin as first-line treatment for sleep disorders in Parkinson’s disease? Read More »
Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and other synucleinopathy patient cohorts. However, there has been confusion about αSyn-SAAs for their methodology, nomenclature, and relative accuracies when
Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most
Neuropathological evidence of body-first vs. brain-first Lewy body disease Read More »
Constipation is the most predominant symptom of Parkinson disease (PD), preceding the occurrence of motor symptoms in some patients, leading to reduced quality of life (QOL). The general approaches for the treatment have some side effects, but probiotics are live or attenuated microorganisms attributed to ameliorating constipation effects. Moreover, as treatments are generally well tolerated and side
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by
Shining light on the head: Photobiomodulation for brain disorders Read More »
Light is essential to life as we know it. Plants rely upon sunlight to generate chemical energy, which is stored in their tissues and fuels various life processes. In turn, animals like us convert the energy from the food that we eat into mechanical energy. Furthermore, we depend upon light energy entering our eyes in order
Is Red Light a Missing Nutrient for Our Health? Podcast with Dr. Michael Hamblin Read More »