December 2021

Attack of the Oligomers – Alpha-synuclein amyloid oligomers and their pathogenic roles

A-Synuclein, Parkinson's Disease /

In “Attack of the Oligomers,” we review how protein oligomersare the primary neurotoxic agents not just in Parkinson’s diseasebut also in Alzheimer’s (where they were discovered first) andother amyloid-related diseases. The oligomers wreak havocthroughout the cell, disrupting membranes and throwing proteinand ion homeostasis out of balance. However, the most criticaldamage in Parkinson’s disease seems to […]

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Parkinson disease: protective role and function of neuropeptides

Parkinson's Disease /

Neuropeptides are bioactive molecules, made up of small chains of amino acids, with many neuromodulatory properties. Several lines of evidence suggest that neuropeptides, mainly expressed in the central nervous system (CNS), play an important role in the onset of Parkinson’s Disease (PD) pathology. The wide spread disruption of neuropeptides has been excessively demonstrated to be

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Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However, whetherthe assay can be used as a robust, quantitative measure to monitor disease progression, stratifydifferent synucleinopathies and predict disease conversion in patients with idiopathic REMsleep behaviour disorder remains undetermined. The aim of this study was

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REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder

iRBD /

Brainstem neurophysiology as evidenced by altered VEMPs in patients with PD and iRBD could reflect disease evolvement. Moreover, VEMPs alterations may vary depending on the presence of RBD in PD patients. The associations between altered RSWA and VEMP parameters highlight the meaningfulness of detecting brainstem dysfunction in early-stage PD. Keywords Parkinson’s disease vestibular-evoked myogenic potentials

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Nocturnal Teeth Grinding Linked With Incidence of Other Sleep-Related Disorders

iRBD, Parkinson's Disease, Pre-PD /

SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson’s disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the above mentioned

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Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease

Autophagy, Parkinson's Disease, Pre-PD /

Cellular quality control systems have gained much attention in recent decades. Amongthese, autophagy is a natural self-preservation mechanism that continuously eliminates toxic cellularcomponents and acts as an anti-ageing process. It is vital for cell survival and to preserve homeostasis.Several cell-type-dependent canonical or non-canonical autophagy pathways have been reportedshowing varying degrees of selectivity with regard to

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THE GUT-BRAIN AXIS: THE ROLE OF NUTRITION

Diet and Exercise, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut-brain axis (GBA) refers to the bi-directional communication thatoccurs between the gut and the brain. Recently, studies have highlightedthe important role of nutrition in modulating the GBA. We will delve into thisexciting area of research and understand how certain diets and foods maybe linked to mood and mental health. Our understanding of the gut-brain

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The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

The gut microbiota is the set of microorganisms present in the gut, and it is connected to the central nervous system via the gut-brain axis. Despite there is not a definitive description of the eubiotic microbiota architecture, numerous studies have demonstrated its involvement in human behaviour and its relationship with several pathologies. This is a systematic review about the association between dysbiosis on

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Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients

iRBD, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD

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