There has been exponential growth in the awareness and understanding of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) over the past 3 decades. The clinical features of GI dysfunction in PD have been clearly identified and innovative research has demonstrated the presence of pathology within the enteric nervous system (ENS) in individuals with PD, leading […]
Gastrointestinal Dysfunction in Parkinson’s Disease Read More »
Background:Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective:To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods:Patients with iRBD were
This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson’s disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. plantarum DP189 increased the levels of superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) and decreased the levels of malondialdehyde (MDA), reactive oxygen species
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eyemovements sleep behavior disorder (iRBD) were compared with 17 patientswith RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated a-synuclein depositsand whole-night video-polysomnography. Skin biopsy was positive for phosphorylated a-synuclein deposits in 86.7% of iRBD patients and in none
Biomarkers for REM sleep behavior disorder in idiopathic
and narcoleptic patients Read More »
: Gut microbiota encompasses a wide variety of commensal microorganisms consisting oftrillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host,and related metabolites have profound effects on human health. In this respect, gut microbiota playsa pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolitesinclude the short
Gut Microbiota and Short Chain Fatty Acids: Implications in
Glucose Homeostasis Read More »
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling Read More »
Parkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied
Gait parameters and a pretrained statistical model can robustly distinguish participants with iRBD from HCs and patients with PD. This could be used to screen subjects with future synucleinopathies in the general population and to identify a conversion threshold to PD. CLICK TO REVIEW
RBD stands for Rapid Eye Movement Disorder and is a sleep disorder that happens duringyour REM (Rapid Eye Movement) stage of sleep. People often associate the cause of RBD with dreamsbecause people dream during the REM stage of sleep, which is also when RBD tends to happen as well.It may affect a small fraction of
Is the cause of RBD neurological or psychological? Read More »
Fasting promotes autophagy, a vital recycling process, and stimulates the growth factor BDNF. Autophagy is impaired in neurodegenerative conditions such as Alzheimer’s and Parkinson’s. BDNF is crucial for brain health, and low levels are associated with depression. Hence, fasting improves brain health by multiple mechanisms. While fasting has been performed in one form or another
Is Fasting Good For Your Brain? The Effects of Fasting on the Brain Read More »