January 2022

Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson’s disease patients

Autonmic nervous system, Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Short Chain Fatty Acids /

Serum SCFAs are altered in PD patients, and the decrease of serum propionic acid level is correlated with motor symptoms, cognitive ability and non-depressed state. Thus, the gut microbial-derived SCFAs potentially affect Parkinson’s symptoms through the blood circulation. Propionic acid supplementation might ameliorate motor and non-motor symptoms of PD patients, although clinical trials are needed […]

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Dairy Intake and Parkinson’s Disease: A Mendelian Randomization Study

Diet and Exercise, Parkinson's Disease /

Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society CLICK TO REVIEW

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Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases

Diet and Exercise, Parkinson's Disease /

Background: Over the last three decades, consumption of total and saturated fat has steadily declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 fatty acid intake has risen at the expense of ω-3 fatty acids, resulting in an ω-6/ω-3 ratio of 20:1 or higher. Scope and approach: The

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Non-Motor Symptoms and Their Associated Factors in Parkinson’s Disease

Biomarkers, Constipation, Dreams, Non-Motor Symptoms, Orthostatic Hypotension /

Background: Parkinson’s disease is a common neurologic ailment that causes tremor and bradykinesia. The prevalenceof Parkinson’s disease is estimated to be 1–2 in 1000, affecting about 1% of the population over the age of 60 years. Theobjective of this study was to find the frequency of Non-Motor Symptoms in patients with Parkinson’s Disease (PD) andits

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MicroRNA Candidate Biomarkers for Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder

Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Current study provides a valuable and highly informative dataset of EV-associated sncRNAsfrom plasma of iRBD and PD patients. We identified miRNA signature features that could serve asminimally-invasive, blood-based surveillance biomarkers for distinguishing iRBD or PD from healthyindividuals with high sensitivity, specificity, and accuracy. CLICK TO REVIEW

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Overview on Parkinson’s disease: pathophysiology, and experimental models

Parkinson's Disease /

Parkinson’s disease, a neurodegenerative disease, is caused by dopaminergic neurons death and accompanied byrigidity, and postural instability, as well as bradykinesia. The cause of these neurons’ death is still unclear. Since thedopaminergic neurons couldn’t regenerate, therefore Parkinson’s disease couldn’t be cured. Thus, over the pastdecades, significant effort has been made to explore the etiology of

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Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases

Diet and Exercise, Parkinson's Disease /

It has been proven that physical exercise improves cognitive function and memory, hasan analgesic and antidepressant effect, and delays the aging of the brain and the development ofdiseases, including neurodegenerative disorders. There are even attempts to use physical activity inthe treatment of mental diseases. The course of most diseases is strictly associated with oxidativestress, which

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Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach

Detox, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and nonmotor complications. Autonomic alterations, including gastrointestinal symptoms, precede motordefects and act as early warning signs. Chronic exposure to dietary, environmental heavy metalsimpacts the gastrointestinal system and host-associated microbiome, eventually affecting the centralnervous system. The correlation between dysbiosis and PD suggests a functional and bidirectionalcommunication

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Gut microbiota related to nutrition and physical activity: an integrative review

Diet and Exercise, Gut Microbiota /

The gut microbiota (GM) is formed by millions of microorganisms present in the gastrointestinal tract, especially in the colon. This intestinal homeostasis can be triggered by the union of a good diet, and even recent studies have suggested that aerobic physical training can modify its composition. Objective:To analyze the influence of healthy eating added to

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Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice

Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Emerging evidence indicates that probiotics can influence the gut–brain axis to ameliorate somatic and behavioral symptoms associated with brain disorders. However, whether probiotics have effects on the electrophysiological activities of individual neurons in the brain has not been evaluated at a single-neuron resolution, and whether the neuronal effects of probiotics depend on the gut microbiome

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