February 2022

Gastrointestinal Microbiome and Neurologic Injury

Butyrate, Constipation, ENS, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

: Communication between the enteric nervous system (ENS) of the gastrointestinal (GI)tract and the central nervous system (CNS) is vital for maintaining systemic homeostasis. Intrinsicand extrinsic neurological inputs of the gut regulate blood flow, peristalsis, hormone release, andimmunological function. The health of the gut microbiome plays a vital role in regulating the overallfunction and well-being […]

Gastrointestinal Microbiome and Neurologic Injury Read More »

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Butyrate, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated with both the potential functionality of the gut microbiota and the biological mechanisms thought to be underpinning mental disorders. In this

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia Read More »

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »

Gut microbiome alterations in fecal samples of treatment-naïve de novo Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Gut microbiota alterations in Parkinson’s disease (PD) have been found in several studies and are suggested to contribute to the pathogenesis of PD. However, previous results could not be adequately adjusted for a potential confounding effect of PD medication and disease duration, as almost all PD participants were already using dopaminergic medication and were included

Gut microbiome alterations in fecal samples of treatment-naïve de novo Parkinson’s disease patients Read More »

Prodromal Parkinson’s disease: hype or hope for disease-modification trials?

Biomarkers, Parkinson's Disease, Pre-PD /

The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modification trials in PD has been attributed to a variety of factors related not only to choosing wrong interventions, but also to using inadequate

Prodromal Parkinson’s disease: hype or hope for disease-modification trials? Read More »

The Complement System in the Central Nervous System:
From Neurodevelopment to Neurodegeneration

Uncategorized /

The functions of the complement system to both innate and adaptive immunity throughopsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond immunity, is only beginning to berecognized as important to neurodevelopment and neurodegeneration. In addition to protecting thebrain against invasive

The Complement System in the Central Nervous System:
From Neurodevelopment to Neurodegeneration Read More »

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

Gut Dysbiosis, Gut Permeability / Leaky Gut, Oral Microbiome /

We found increasing gut-dysbiosis with worsening symptoms in sALS patients and increasing oral-dysbiosis with worsening symptoms in bALS patients. Our findings support distinct microbial mechanisms underlying two ALS subtypes, which have been previously grouped together as a single disease. Our study suggests correcting gut-dysbiosis as a therapeutic strategy for sALS patients and correcting oral-dysbiosis as

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset Read More »

Adult Neurogenesis under Control of the Circadian System

Photobiomodulation (PBM) /

The mammalian circadian system is a hierarchically organized system, which controls a24-h periodicity in a wide variety of body and brain functions and physiological processes. Thereis increasing evidence that the circadian system modulates the complex multistep process of adultneurogenesis, which is crucial for brain plasticity. This modulatory effect may be exercised viarhythmic systemic factors including

Adult Neurogenesis under Control of the Circadian System Read More »

Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases

A-Synuclein, Autonmic nervous system, Biomarkers, Gut-Brain axis /

Neurodegenerative diseases are hitherto classified based on their core clinical features, the anatomical distribution of neurodegeneration, and the cell populations mainly affected. On the other hand, the wealth of neuropathological, genetic, molecular and biochemical studies have identified the existence of distinct insoluble protein aggregates in the affected brain regions. These findings have spread the use of a

Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases Read More »

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers

iRBD, Parkinson's Disease, Pesticides, Pre-PD /

Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological evidence is limited. This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream-enacting behaviors. CLICK

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers Read More »