Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression. From our translational study, which included 3 animal models […]
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally invital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protectionagainst the development of neurological diseases. Emerging evidence shows that gut microbiotahave significant roles in maintaining adequate concentrations of
Role of Microbiota-Gut-Brain Axis in Regulating
Dopaminergic Signaling Read More »
Regular treadmill exercise is more efficient than voluntary in neuroprotection by changing brain metabolism, at the moment, regulartreadmill exercise has been observed to improve many physiological impacts in humans and animals. The present study sought to verifythe effect of regular treadmill exercise on brain-derived neurotrophic factor (BDNF) and irisin in healthy adult’s men in Basra
The use of psychedelics as medicines and for overall better brain health is potentially one of the mosttransformative developments given their immediate and long-lasting therapeutic effects across a plethoraof neuropsychiatric disorders and, more recently, some neurodegenerative diseases. The US psychedelicdrugs market is forecasted to grow by 16.3% by 2027 due to the increasing prevalence of
The promise of psychedelic research Read More »
Parkinson’s disease (PD) is a threatening neurodegenerative disorder that seriously affects patients’ life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (α-Syn) to PD. α-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic
α-Synuclein in Parkinson’s disease and advances in detection Read More »
To estimate the health-promoting effects of Lacticaseibacillus paracasei (previously Lactobacillus casei) strainShirota (LcS) that reached the lower gastrointestinal tract alive, we investigated the characteristics of gut microbiome,organic acid profiles, defecatory symptoms and serum viral antibody indexes of healthy Japanese adults between thegroup in whom live LcS was detected or not from stool. The β-diversity index
Parkinson’s disease (PD) is a progressive neurodegenerative disease, causing loss of motor and nonmotor function. Diagnosis is based on clinical symptoms that do not develop until late in the disease progression, at which point the majority of the patients’ dopaminergic neurons are already destroyed. While many PD cases are idiopathic, hereditable genetic risks have been
Plasma Metabolite Signature Classifies Male LRRK2 Parkinson’s Disease Patients Read More »
Parkinson’s disease (PD) is one of the first diseases where digital biomarkers demonstrated excellent performance in differentiating disease from healthy individuals. However, no study has systematically compared and leveraged multiple types of digital biomarkers to predict PD. Particularly, machine learning works on the fine-motor skills of PD are limited. Here, we developed deep learning methods
Sialic acid–protein interactions are involved in regulating central nervous systemimmunity; therefore, derangements in sialylation could beinvolved in neurodegeneration. Decreased serum CDTadj is associatedwith substantia nigra degeneration in synucleinopathies.iRBD patients with low CDTadj are more likely tophenoconvert to manifest disease. CLICK TO REVIEW
Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can
Parkinson’s disease: Are gut microbes involved? Read More »