Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical PD motor symptoms. The therapeutic effect of cannabidiol (CBD) on PD has been a research frontier in recent years. However, the pathogenesis of PD and the therapeutic mechanism of cannabinoid remain unclear. To further […]
Fermented foods are among the traditional foods consumed for centuries. In recent years, awareness of fermented foods has been increasing due to their positive health benefits. Fermented foods contain beneficial microorganisms. Fermented foods, such as kefir, kimchi, sauerkraut, and yoghurt, contain Lactic acid bacteria (LAB), such as Lactobacilli, Bifidobacteria, and their primary metabolites (lactic acid). Although studies on
Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinalmicrobiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linkedto inflammation. Here, we aim to define the impact of specific foods on bacterial species commonlydepleted in patients with IBD to better inform dietary treatment. We performed a single-arm, prepost
Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of theinnate immune system, produced without prior contact to their specific antigen, and polyreactive.The abundance of nAbs against αSyn is altered in patients with PD. In this work, we biophysicallycharacterized nAbs against
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the cardinal features of tremor, bradykinesia, rigidity, and postural instability, in addition to other non-motor symptoms. Pathologically, PD is attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta, with the hallmark of the presence of intracellular protein aggregates of α-synuclein in
Neurodegenerative protein conformational diseases are characterized by misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous work, suggest
Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis Read More »
Psychobiotics are an emerging class of probiotics that, when ingested in ample amounts, confer mental health benefits through interacting with gastrointestinal (GI) microbiota in patients with psychiatric problems. These mind-altering groups of probiotics modulate the functions and behavior of the central nervous system via the gut–brain axis to improve GI health and exert anxiolytic and
Psychobiotics in Health, Longevity, and Neurological Disorders Read More »
Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and to be key mediators in the gut-bone signaling axis. However, the role of SCFAs in bone fracture healing and its impact on systemic inflammation during the regeneration process has not been extensively
Parkinson’s disease (PD), the second most common progressive neurodegenerative disease,develops and progresses for 10-15 years before the clinical diagnostic symptoms of thedisease are manifested. Furthermore, several aspects of PD pathology overlap with otherneurodegenerative diseases (NDDs) linked to alpha-synuclein aggregation, also calledsynucleinopathies. Therefore, there is an urgent need to discover and validate earlydiagnostic and prognostic markersthat
Individuals exposed to PID were 1.431 times more likely to develop PD than those who were not exposed. However, future long-term, larger or national data sets combined with genes, environmental exposure, lifestyle changes, dietary habits, and accurately defined PD diagnosis should be investigated to support the current research results. CLICK TO REVIEW