April 2022

Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics

Diet and Exercise, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Inulin consumption in both humans and animal models is recognized for its prebiotic action with the most consistent change that lies in enhancing the growth and functionality of Bifidobacterium bacteria, as well as its effect on host gene expression and metabolism. Further, inulin-type fructans are utilized in the colon by bacterial fermentation to yield short-chain fatty acids (SCFAs), which play […]

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Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?

Enviromental, Glyphosate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Read More »

Recent advances in understanding the roles of the enteric nervous system

ENS, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its complex circuitry and neuronal diversity, the ENS is capable of functioning autonomously but is modulated by inputs from the central nervous system (CNS). The communication between

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Impact of environmental toxicants exposure on gut-brain axis in Parkinson disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a major public health challenge as many of the current drugs used in its management provide symptomatic relieve without preventing the underlying cause of the neurodegeneration. Similarly, the non-motor complications of PD, especially the gastrointestinal tract (GIT) disturbance increases the disease burden on both the PD patient and caregivers. Different theories

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Chaperone-Mediated Autophagy in Neurodegenerative
Diseases and Acute Neurological Insults in the Central
Nervous System

Autophagy, Parkinson's Disease, Pre-PD /

Autophagy is an important function that mediates the degradation of intracellular proteinsand organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucialrole in cellular proteostasis under various physiological and pathological conditions. CMA dysfunction leads to the accumulation of toxic protein aggregates in the central nervous system (CNS) andis involved in the pathogenic process of

Chaperone-Mediated Autophagy in Neurodegenerative
Diseases and Acute Neurological Insults in the Central
Nervous System Read More »

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease.Prevention of neuroinflammation in Parkinson’s disease

Diet and Exercise, Fasting, Parkinson's Disease, Therapies /

Parkinson’s disease (PD) is the second most common age-associated neurodegenerative disorder and is characterized by progressive loss of dopamine neurons in the substantia nigra. Peripheral immune cell infiltration and activation of microglia and astrocytes are observed in PD, a process called neuroinflammation. Neuroinflammation is a fundamental response to protect the brain but, when chronic, it

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease.Prevention of neuroinflammation in Parkinson’s disease Read More »

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate

Butyrate, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids /

Our data indicate a cause–effect relationship between gut microbiota and PSCI for the first time, which is likely mediated by inflammation-regulating metabolites including LPS and butyrate. CLICK TO REVIEW

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate Read More »

Preventing Bacterial Translocation in Patients with Leaky Gut
Syndrome: Nutrition and Pharmacological Treatment Options

Gut Dysbiosis, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

: Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability.Since the intestinal barrier is one of the essential components maintaining homeostasis along thegastrointestinal tract, loss of its integrity due to changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokinesmay lead to intestinal hyperpermeability followed by

Preventing Bacterial Translocation in Patients with Leaky Gut
Syndrome: Nutrition and Pharmacological Treatment Options Read More »

Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression

iRBD, Parkinson's Disease, Pre-PD /

The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up

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Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients

Diet and Exercise, endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD, Root Canal /

Oral disorders are frequent in PD. Good knowledge of these alterations will allow us to design a specific preventive protocol. Some oral alterations may be a sign of diagnostic alert or progression of PD. CLICK TO REVIEW

Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients Read More »