April 2022

Recent advances in understanding the roles of the enteric nervous system

Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its complex circuitry and neuronal diversity, the ENS is capable of functioning autonomously but is modulated by inputs from the central nervous system (CNS). The communication between […]

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Effects of a Ketogenic Diet on Symptoms, Biomarkers, Depression, and Anxiety in Parkinson’s Disease: A Case Study

Diet and Exercise, Parkinson's Disease /

The ketogenic diet has grown in popularity as an alternative or adjunct to medication therapy for Parkinson’s disease (PD) and other neurodegenerative diseases (NDD). Traditional medication therapies often fail to produce desired improvements in PD symptoms and can have little or no effect on symptoms of depression and anxiety that often accompany a PD diagnosis. We

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Evaluating the Role of Probiotics in the Prevention and
Management of Age-Related Diseases

Butyrate, Diet and Exercise, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

: The human lifespan has been significantly increased due to scientific advancements inthe management of disease; however, the health span of the aging population does not follow thesame trend. Aging is the major risk factor for multimorbidity that is derived from the progressiveloss of homeostasis, immunological and stem cell exhaustion, as well as exacerbated inflammationresponses.

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Management of Age-Related Diseases Read More »

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights

A-Synuclein, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights Read More »

Food Contamination: An Unexplored Possible Link between
Dietary Habits and Parkinson’s Disease

Diet and Exercise, Enviromental, Glyphosate, Lectins, Parkinson's Disease, Pesticides /

Importance of a healthy lifestyle in maintaining the population’s well-being and health,especially in terms of balanced nutrition, is well known. Food choice of and dieting habits couldimpact disease management, which is especially true for Parkinson’s disease (PD). However, nowadays, it is not that simple to maintain a balance in nutrition, and the idea of a

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Dietary Habits and Parkinson’s Disease Read More »

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has

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Lipopolysaccharide mouse models for Parkinson’s disease research

Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD /

a critical appraisal Parkinson’s disease, the most common movement disorder, has a strong neuroinflammatory aspect. This is evident by increased pro-inflammatory cytokines in the serum, and the presence of activated microglial cells, and inflammatory cytokines in the substantia nigra of post-mortem brains as well as cerebrospinal fluid of Parkinson’s disease patients. The central and peripheral

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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential

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Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease

A-Synuclein, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α-synuclein (α-syn) in their colon. Both

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