At 12 weeks post-injection, a separate 43 and distinct pattern of structural and sensory-evoked functional brain activity changes was 44 observed that are co-localized with previously reported regions of α-syn pathology and immune 45 activation. Microstructural changes in the pons at 12 weeks post-injection were found to predict 46 survival time and preceded measurable locomotor deficits. This study provides preliminary 47 evidence for diffusion and functional MRI markers linked to the progression of synuclein 48 pathology and has translational importance for understanding synucleinopathies in humans. CLICK TO REVIEW