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Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort

Biomarkers, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain […]

Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort Read More »

Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells

Gut Dysbiosis, Gut Microbiota, Oral Microbiome /

Background Recent epidemiological studies have shown that inflammatory bowel disease is associated with periodontal disease. The oral-gut microbiota axis is a potential mechanism intersecting the two diseases. Porphyromonas gingivalis is currently considered a keystone oral pathogen involved in periodontal disease pathogenesis and disease progression. Recent studies have shown that oral ingestion of P. gingivalis leads to intestinal inflammation. However,

Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells Read More »

Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: Effect of speaking task and ambient noise

Biomarkers, Dysphonia (declining volume), iRBD /

ABSTRACT Although the cepstral peak prominence (CPP) and its variant, the cepstral peak prominence smooth (CPPS), are considered to be robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate the voice changes via

Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: Effect of speaking task and ambient noise Read More »

Cognition and driving ability in isolated and symptomatic REM sleep behavior disorder

iRBD, Non-Motor Symptoms /

Study Objectives To analyze cognitive deficits leading to unsafe driving in patients with REM Sleep Behavior Disorder (RBD), strongly associated with cognitive impairment and synucleinopathy-related neurodegeneration.Methods Twenty isolated RBD (iRBD), 10 symptomatic RBD (sRBD), and 20 age- and education-matched controls participated in a prospective case-control driving simulation study. Group mean differences were compared with correlations

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Environmental triggers of Parkinson’s disease – Implications of the Braak and dual-hit hypotheses

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Olfactory, Parkinson's Disease, Pre-PD /

Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD

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Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysis

A-Synuclein, Biomarkers, Hyposmia, Hyposmia, iRBD, Orthostatic Hypotension /

Background A number of promising biomarkers for predicting imminent α-synucleinopathies have been suggested in isolated rapid eye movement sleep behaviour disorder (iRBD). However, existing evidence is conflicting without quantitative evaluation. Methods PubMed, Web of Science and ClinicalTrials.gov were searched through June 2021 to identify possible predictors of phenoconversion from iRBD to Parkinson’s disease (PD). The pooled HRs

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A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis

Oral Microbiome, Periodontitis /

Periodontal disease (PDD) and rheumatoid arthritis (RMA) share comparative pathophysiological pathways like ongoingaggravation with resorption of the proximal bone in immunologically delicate hosts; However, PDD has a notable bacteriological etiology, and the cause of RMA remains unknown. According to some reports, an infectious agent in a vulnerable host may be the cause of RMA and

A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis Read More »

Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging

iRBD, Pre-PD /

BACKGROUND: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is one of the earliest manifestations of α synucleinopathies. Brainstem pathophysiology underlying REM sleep behavior disorder has been described in animal models, yet it is understudied in living humans because of the lack of an in vivo brainstem nuclei atlas and to the limited magnetic

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Relationship between mild traumatic brain injury and the gut microbiome: A scoping review

Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

There is increasing evidence for the important role of gut microbiota (GMB) in the development and progression of neurologic pathologies. Some studies have shown that modifying the microbiome profile can confer benefits to patients. Mild traumatic brain injury (mTBI) is a common occurrence in the general population. Although most patients recover, in a minority, disabling

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Modifying the Microbiome as a Potential Mechanism of Photobiomodulation: A Case Report

Gut Dysbiosis, Gut Microbiota, Photobiomodulation (PBM) /

Objective: The objective of this case study was to elucidate the effect of photobiomodulation (PBM) on the microbiome. Background: The gut microbiome has been identified as a key component of health, with gut dysbiosis, characterized by decreased microbial diversity and an altered microbial composition, being recognized as instrumental in many diseases and disorders. Previous research has suggested

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